Results 101 to 110 of about 238,298 (223)

Immobilizing the Moving Parts of Voltage-Gated Ion Channels

The Journal of General Physiology, 2000
Voltage-gated ion channels have at least two classes of moving parts, voltage sensors that respond to changes in the transmembrane potential and gates that create or deny permeant ions access to the conduction pathway.
R. Horn, S. Ding, H. Gruber
semanticscholar   +1 more source

Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

Nature Communications, 2019
Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD).
João L. Carvalho-de-Souza, Francisco Bezanilla   +1 more
doaj   +1 more source

Cellular and Molecular Targets of Menthol Actions

Frontiers in Pharmacology, 2017
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent.
Murat Oz, Murat Oz, Eslam G. El Nebrisi, Keun-Hang S. Yang, Frank C. Howarth, Lina T. Al Kury   +5 more
doaj   +1 more source

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons

, 2009
We investigate the regularity of spontaneous spiking activity on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise and fraction of blocked voltage-gated sodium and ...
Ozer, Mahmut, Perc, Matjaz, Uzuntarla, Muhammet   +2 more
core   +1 more source

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases

Frontiers in Cellular Neuroscience
Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-
Janire Urrutia, Ane Arrizabalaga-Iriondo, Ana Sanchez-del-Rey, Agustín Martinez-Ibargüen, Mónica Gallego, Oscar Casis, Miren Revuelta   +6 more
doaj   +1 more source

Voltage-Gated Ion Channels and the Variability in Information Transfer. [PDF]

Front Cell Neurosci, 2022
Rathour RK, Kaphzan H.
europepmc   +1 more source

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

PLoS Computational Biology, 2007
The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
doaj   +1 more source