Results 51 to 60 of about 2,607,690 (301)
Voltage-Gated Ion Transport in Two-Dimensional Sub-1-Nanometer Nanofluidic Channels.
ACS Nano, 2019 Voltage-gated nanofluidic systems have shown a wide range of potential applications in biosensors, energy harvest and separation. Two-dimensional (2D) nanofluidic membranes fabricated with electrically conductive nanosheets have high ion conductivity and
Yuqi Wang +5 more
semanticscholar +1 more source
Voltage-Gated Potassium Channels as Regulators of Cell Death
Frontiers in Cell and Developmental Biology, 2020 Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann +9 more
doaj +1 more source
The influence of lipids on voltage-gated ion channels [PDF]
Current Opinion in Structural Biology, 2012 Voltage-gated ion channels are responsible for transmitting electrochemical signals in both excitable and non-excitable cells. Structural studies of voltage-gated potassium and sodium channels by X-ray crystallography have revealed atomic details on their voltage-sensor domains (VSDs) and pore domains, and were put in context of disparate mechanistic ...
Qiu-Xing, Jiang, Tamir, Gonen
openaire +2 more sources
Journal of pharmacological and toxicological methods, 2017 Voltage gated ion channels are central in defining the fundamental properties of the ventricular cardiac action potential (AP), and are also involved in the development of drug-induced arrhythmias.
Hai Huang +6 more
semanticscholar +1 more source
Voltage-Gated Ion Channels and Electrical Excitability [PDF]
Neuron, 1998 Our original research has been generously supported over many years by National Institutes of Health grants NS08174 and NS12547.
Armstrong, Clay M, Hille, Bertil
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Advanced Functional Materials, 2018 Organic semiconductors are emerging as promising candidates for novel electrically self‐sufficient photovoltaic prosthetics for neurostimulation, especially for restoration of light sensitivity in degenerate retina. Considering future applications, it is
Oliya S Abdullaeva +6 more
semanticscholar +1 more source
Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex
Frontiers in Molecular NeuroscienceTuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt +2 more
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Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology
eLife, 2019 Conductance in voltage-gated ion channels is regulated by membrane voltage through structural domains known as voltage sensors. A single structural class of voltage sensor domain exists, but two different modes of voltage sensor attachment to the pore ...
Xiao Tao, Roderick MacKinnon
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Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments.
TIPS - Trends in Pharmacological SciencesEpileptic encephalopathies are generally considered to be functional disruptions in the balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion channels are key targets of antiepileptic drugs, playing a critical role
D. Debanne +3 more
semanticscholar +1 more source
Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold
ChannelsIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen +5 more
doaj +1 more source