Results 41 to 50 of about 2,607,690 (301)

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Frontiers in Pharmacology, 2012
Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca, Scott K Adney, Lei eZhou, Diomedes E Logothetis   +3 more
doaj   +1 more source

Hysteretic Behavior in Voltage-Gated Channels

Frontiers in Pharmacology, 2020
An ever-growing body of evidence has shown that voltage-gated ion channels are likely molecular systems that display hysteresis in their activity. This phenomenon manifests in the form of dynamic changes in both their voltage dependence of activity and ...
Carlos A. Villalba-Galea, Alvin T. Chiem
doaj   +1 more source

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Frontiers in Pharmacology, 2012
Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate.
Frank S Choveau, Frank S Choveau, Frank S Choveau, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Zeineb eEs-Salah-Lamoureux, Fabien C Coyan, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Isabelle eBaro, Isabelle eBaro, Gildas eLoussouarn, Gildas eLoussouarn, Gildas eLoussouarn   +17 more
doaj   +1 more source

Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]

, 2008
Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P., Smith, Peter J. S., Messerli, Mark A., Smith, Peter J.S.   +3 more
core   +1 more source

Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes. [PDF]

PLoS ONE, 2016
The ability of azobenzene trimethylammonium bromide (azoTAB) to sensitize cardiac tissue excitability to light was recently reported. The dark, thermally relaxed trans- isomer of azoTAB suppressed spontaneous activity and excitation propagation speed ...
Sheyda R Frolova, Olga Gaiko, Valeriya A Tsvelaya, Oleg Y Pimenov, Konstantin I Agladze   +4 more
doaj   +1 more source

A Sea Anemone Lebrunia neglecta Venom Fraction Decreases Boar Sperm Cells Capacitation: Possible Involvement of HVA Calcium Channels

Toxins, 2022
Sea anemones produce venoms characterized by a complex mixture of low molecular weight compounds, proteins and peptides acting on voltage-gated ion channels. Mammal sperm cells, like neurons, are characterized by their ion channels. Calcium channels seem
Fernando Lazcano-Pérez, Karina Bermeo, Héctor Castro, Zayil Salazar Campos, Isabel Arenas, Ariana Zavala-Moreno, Sheila Narayán Chávez-Villela, Irma Jiménez, Roberto Arreguín-Espinosa, Reyna Fierro, Humberto González-Márquez, David E. Garcia, Judith Sánchez-Rodríguez   +12 more
doaj   +1 more source

Kv7 and Kv11 channels in myometrial regulation. [PDF]

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid, Greenwood, IA, Rachel M. Tribe, Greenwood, Iain, Iain A. Greenwood, Tribe, RM   +5 more
core   +1 more source

Cnidarian Toxins Acting on Voltage-Gated Ion Channels

Marine Drugs, 2006
: Voltage-gated ion channels generate electrical activity in excitable cells. As such, they are essential components of neuromuscular and neuronal systems, and are targeted by toxins from a wide variety of phyla, including the cnidarians. Here, we review
Robert M. Greenberg, Shanta M. Messerli
doaj   +1 more source