Results 21 to 30 of about 65,501 (244)

Voltage‐Gated Ion Channels: Structure, Pharmacology and Photopharmacology

ChemPhysChem
AbstractVoltage‐gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. Over the last decade, advancements have enabled the elucidation of crystal structures of ion channels.
Shirin Faraji, Juan J Nogueira
exaly   +5 more sources

Voltage-gated ion channels as novel regulators of epithelial ion transport in the osmoregulatory organs of insects [PDF]

Frontiers in Insect Science
Dennis Kolosov
exaly   +2 more sources

Voltage-Gated Ion Channels [PDF]

IEEE Transactions on Nanobioscience, 2005
Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
  +7 more sources

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel

eLife, 2022
Voltage-gated proton (Hv) channels are standalone voltage sensors without separate ion conductive pores. They are gated by both voltage and transmembrane proton gradient (i.e., ∆pH), serving as acid extruders in most cells.
Shuo Han, Sophia Peng, Joshua Vance, Kimberly Tran, Nhu Do, Nauy Bui, Zhenhua Gui, Shizhen Wang   +7 more
doaj   +1 more source

Ion channels as molecular targets of glioblastoma electrotherapy

Frontiers in Cellular Neuroscience, 2023
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma.
Tayeb Abed, Katrin Ganser, Franziska Eckert, Franziska Eckert, Nicolai Stransky, Nicolai Stransky, Stephan M. Huber   +6 more
doaj   +1 more source

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels [PDF]

Frontiers in Physiology, 2017
Fredrik Elinder, Sara I Liin, Elinder Fredrik   +2 more
exaly   +2 more sources

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2023
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj   +1 more source

Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms

eLife, 2020
The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden ...
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson   +7 more
doaj   +1 more source

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source