Results 21 to 30 of about 2,616,993 (275)

Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots. [PDF]

PLoS ONE, 2010
Voltage-gated ion channels are main players involved in fast synaptic events. However, only slow intracellular mechanisms have so far been described for controlling their localization as real-time visualization of endogenous voltage-gated channels at ...
David Gómez-Varela, Tobias Kohl, Manuela Schmidt, María E Rubio, Hiroshi Kawabe, Ralf B Nehring, Stephan Schäfer, Walter Stühmer, Luis A Pardo   +8 more
doaj   +1 more source

Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles. [PDF]

PLoS ONE, 2011
Voltage-gated ion channels are key players in cellular excitability. Recent studies suggest that their behavior can depend strongly on the membrane lipid composition and physical state. In vivo studies of membrane/channel and channel/channel interactions
Sophie Aimon, John Manzi, Daniel Schmidt, Jose Antonio Poveda Larrosa, Patricia Bassereau, Gilman E S Toombes   +5 more
doaj   +1 more source

Contribution of Axon Initial Segment Structure and Channels to Brain Pathology

Cells, 2023
Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
doaj   +1 more source

Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]

, 2014
Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core   +1 more source

Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels [PDF]

, 2003
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A, Helmstaedter, M., Helmstaedter, Moritz, Schaefer, AT, Korngreen, A., Schaefer, A., Sakmann, Bert, Helmstaedter, M, Sakmann, B, Schaefer, Andreas T., Korngreen, Alon, Sakmann, B., Helmstädter, Moritz   +12 more
core   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Frontiers in Pharmacology, 2012
Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca, Scott K Adney, Lei eZhou, Diomedes E Logothetis   +3 more
doaj   +1 more source

Hysteretic Behavior in Voltage-Gated Channels

Frontiers in Pharmacology, 2020
An ever-growing body of evidence has shown that voltage-gated ion channels are likely molecular systems that display hysteresis in their activity. This phenomenon manifests in the form of dynamic changes in both their voltage dependence of activity and ...
Carlos A. Villalba-Galea, Alvin T. Chiem
doaj   +1 more source

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Frontiers in Pharmacology, 2012
Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate.
Frank S Choveau, Frank S Choveau, Frank S Choveau, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Zeineb eEs-Salah-Lamoureux, Fabien C Coyan, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Isabelle eBaro, Isabelle eBaro, Gildas eLoussouarn, Gildas eLoussouarn, Gildas eLoussouarn   +17 more
doaj   +1 more source