Results 11 to 20 of about 2,607,690 (301)
Voltage‐Gated Ion Channels: Structure, Pharmacology and Photopharmacology
ChemPhysChemAbstractVoltage‐gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. Over the last decade, advancements have enabled the elucidation of crystal structures of ion channels.
Juan JOSÉ Nogueira, Shirin Faraji
exaly +6 more sources
Voltage-Gated Ion Channels in Neuropathic Pain Signaling. [PDF]
Life (Basel)Neuropathic pain is a chronic and debilitating disorder of the somatosensory system that affects a significant proportion of the population and is characterized by abnormal responses such as hyperalgesia and allodynia.
Felix R, Corzo-Lopez A, Sandoval A.
europepmc +3 more sources
Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels. [PDF]
Front Physiol, 2017 Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage ...
Elinder F, Liin SI.
europepmc +3 more sources
Voltage-Gated Ion Channels and the Variability in Information Transfer. [PDF]
Front Cell Neurosci, 2022 Rathour RK, Kaphzan H.
europepmc +2 more sources
In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins. [PDF]
Nat Commun, 2022 Photoactivatable drugs targeting ligand-gated ion channels open up new opportunities for light-guided therapeutic interventions. Photoactivable toxins targeting ion channels have the potential to control excitable cell activities with low invasiveness ...
Montnach J +15 more
europepmc +2 more sources
Recent advances in the pharmacology of voltage-gated ion channels. [PDF]
Pharmacol RevVoltage-gated ion channels (VGICs) are critical regulators of membrane potential, cellular excitability, and calcium signaling in both excitable and nonexcitable tissues and constitute important drug targets for neurological, cardiovascular, and ...
Lopez-Mateos D +4 more
europepmc +2 more sources
Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels. [PDF]
Biophys J, 2020 Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell.
Rems L +3 more
europepmc +2 more sources
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
+7 more sources
Drug binding sites on Nat1.8 sodium channels [PDF]
, 2008 The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core +6 more sources
Structure and function of potassium and calcium channels [PDF]
, 2005 In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core +7 more sources