Results 31 to 40 of about 2,616,993 (275)
Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]
, 2008 Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P. +3 more
core +1 more source
Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes. [PDF]
PLoS ONE, 2016 The ability of azobenzene trimethylammonium bromide (azoTAB) to sensitize cardiac tissue excitability to light was recently reported. The dark, thermally relaxed trans- isomer of azoTAB suppressed spontaneous activity and excitation propagation speed ...
Sheyda R Frolova +4 more
doaj +1 more source
Toxins, 2022 Sea anemones produce venoms characterized by a complex mixture of low molecular weight compounds, proteins and peptides acting on voltage-gated ion channels. Mammal sperm cells, like neurons, are characterized by their ion channels. Calcium channels seem
Fernando Lazcano-Pérez +12 more
doaj +1 more source
Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +1 more source
Cnidarian Toxins Acting on Voltage-Gated Ion Channels
Marine Drugs, 2006 : Voltage-gated ion channels generate electrical activity in excitable cells. As such, they are essential components of neuromuscular and neuronal systems, and are targeted by toxins from a wide variety of phyla, including the cnidarians. Here, we review
Robert M. Greenberg, Shanta M. Messerli
doaj +1 more source
Voltage-Gated Potassium Channels as Regulators of Cell Death
Frontiers in Cell and Developmental Biology, 2020 Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann +9 more
doaj +1 more source
The influence of lipids on voltage-gated ion channels [PDF]
Current Opinion in Structural Biology, 2012 Voltage-gated ion channels are responsible for transmitting electrochemical signals in both excitable and non-excitable cells. Structural studies of voltage-gated potassium and sodium channels by X-ray crystallography have revealed atomic details on their voltage-sensor domains (VSDs) and pore domains, and were put in context of disparate mechanistic ...
Qiu-Xing, Jiang, Tamir, Gonen
openaire +2 more sources
Voltage-Gated Ion Channels and Electrical Excitability [PDF]
Neuron, 1998 Our original research has been generously supported over many years by National Institutes of Health grants NS08174 and NS12547.
Armstrong, Clay M, Hille, Bertil
openaire +2 more sources
Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex
Frontiers in Molecular NeuroscienceTuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt +2 more
doaj +1 more source
Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
eLife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang +2 more
doaj +1 more source