Results 71 to 80 of about 238,298 (223)
Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. [PDF]
PLoS Genetics, 2013 Voltage-gated ion channels are essential for electrical signaling in neurons and other excitable cells. Among them, voltage-gated sodium and calcium channels are four-domain proteins, and ion selectivity is strongly influenced by a ring of amino acids in
Tianxiang Zhang +7 more
doaj +1 more source
Roles for Countercharge in the Voltage Sensor Domain of Ion Channels
Frontiers in Pharmacology, 2020 Voltage-gated ion channels share a common structure typified by peripheral, voltage sensor domains. Their S4 segments respond to alteration in membrane potential with translocation coupled to ion permeation through a central pore domain.
James R. Groome +2 more
doaj +1 more source
Progress on role of ion channels of cardiac fibroblasts in fibrosis
Frontiers in Physiology, 2023 Cardiac fibrosis is defined as excessive deposition of extracellular matrix (ECM) in pathological conditions. Cardiac fibroblasts (CFs) activated by injury or inflammation differentiate into myofibroblasts (MFs) with secretory and contractile functions ...
Chenxv Xing +3 more
doaj +1 more source
HODGKIN-HUXLEY MODEL FOR ACTION POTENTIAL: MEMRISTIVE CHARACTERISTICS [PDF]
, 2012 poster abstractMemristor, a short for memory resistor, is the fourth ideal circuit element whose value varies as a function of charge that has passed through the de-vice.
Joglekar, Yogesh, Mirza, Qurat-ul-Ann
core
Membrane mechanics as a probe of ion-channel gating mechanisms [PDF]
, 2008 The details of conformational changes undergone by transmembrane ion channels in response to stimuli, such as electric fields and membrane tension, remain controversial.
Kondev, Jane +4 more
core +1 more source
Ion Channel Genes in Painful Neuropathies
Biomedicines, 2023 Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska +4 more
doaj +1 more source
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]
, 2015 Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro +7 more
core +2 more sources
Scientific Reports, 2016 Voltage-sensor domains (VSDs) are modular transmembrane domains of voltage-gated ion channels that respond to changes in membrane potential by undergoing conformational changes that are coupled to gating of the ion-conducting pore.
Carus Lau, G. King, M. Mobli
semanticscholar +1 more source
Mechanism of electromechanical coupling in voltage-gated potassium channels
Frontiers in Pharmacology, 2012 Voltage-gated ion channels play a central role in the generation of action potentials in the nervous system. They are selective for one type of ion – sodium, calcium or potassium. Voltage-gated ion channels are composed of a central pore that allows ions
Rikard eBlunck +3 more
doaj +1 more source
PSIONplusm Server for Accurate Multi-Label Prediction of Ion Channels and Their Types
Biomolecules, 2020 Computational prediction of ion channels facilitates the identification of putative ion channels from protein sequences. Several predictors of ion channels and their types were developed in the last quindecennial.
Jianzhao Gao +3 more
doaj +1 more source