Results 211 to 220 of about 2,245,116 (239)

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Opportunities for 2D‐Material‐Based Multifunctional Devices and Systems in Bioinspired Neural Networks

Small, EarlyView.
Bio‐inspired computing offers a route to highly energy‐efficient artificial intelligence. The unique physical properties of two‐dimensional (2D) materials can further enhance such computing approaches. This perspective highlights recent developments in 2D materials‐based neuromorphic devices and discusses future opportunities for integrating such novel
Jin Feng Leong, Maheswari Sivan, Jieming Pan, Zihang Fang, Jianan Li, Zefeng Xu, Shi Zhao, Quanzhen Wan, Evgeny Zamburg, Aaron Voon‐Yew Thean   +9 more
wiley   +1 more source

Impacts of Fluorination at the Ortho‐Position of Carboxy Groups on Tetrakis(biphenyl)ethene‐Based Hydrogen‐Bonded Framework

Small, EarlyView.
This work provides new findings on the effect of fluorination on the substitution of TPE derivatives and the modulation of the structure and fluorescence properties of hydrogen‐bonded organic framework (HOF) of F‐CBPE. ABSTRACT Fluorination of building block molecules is one of the effective engineering approaches to modulate molecular assembly in ...
Takuto Fujii, Mario de la Hoz Tomás, Ryusei Oketani, Boiko Cohen, Ken‐ichi Otake, Kazuki Shiga, Norimitsu Tohnai, Abderrazzak Douhal, Ichiro Hisaki   +8 more
wiley   +1 more source

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

Small, EarlyView.
The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato   +10 more
wiley   +1 more source

Fluorescence Sensing of Anions Like Adenosine 5ʹ‐Triphosphate With pH‐Gated Porous Dye‐Loaded Cerasomes

Small, EarlyView.
The development of gated systems enabling controlled pore opening offers new opportunities for sensing applications. This study explores dye loading in porous and non‐porous cerasomes and pH‐dependent ATP‐triggered gating via polyamine anchors. Porous cerasomes were synthesized using block‐co‐polymers, enabling controlled proton influx and fluorescence‐
Romane Vinot, Estela Climent, Maja Friedrich, Jérémy Bell, Knut Rurack   +4 more
wiley   +1 more source

Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach

Small, EarlyView.
A dual‐thread embroidered SmartBra integrates silver‐plated and conductive‐polymer (PECOTEX) threads to enable simultaneous cardiac monitoring and open‐circuit potentiometric sensing of potassium and sodium in a breast milk substitute. The wearable platform is fabricated using computerized embroidery, offering a scalable, proof‐of‐concept route toward ...
Taliya Weinstein, Xintong Li, Hasan Kurt, Selin Olenik, Alexander Silva‐Pinto Collins, José Manuel Rodrigueiro Flauzino, Muhammed Adeel, Laura Gonzalez‐Macia, Meral Yüce, Firat Güder   +9 more
wiley   +1 more source

ON/OFF Phenomenon in 4‐Aminopyridine Therapy in Spinocerebellar Ataxia 27B: Therapeutic and Diagnostic Insights

Movement Disorders Clinical Practice, EarlyView.
Chiara Caneda, Eleonora Bertoncello, Alessia Peghin, Sara Satolli, Filippo Maria Santorelli, Michele Tinazzi, Ilaria Antonella Di Vico   +6 more
wiley   +1 more source

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Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Channels, 2023
Raymond Norton, K George Chandy, Karoline Sanches   +2 more
exaly