Results 91 to 100 of about 2,526,088 (292)

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif [PDF]

, 2010
The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg, Vicenta Salvador-Recatala   +1 more
core  

Annotation of functional impact of voltage-gated sodium channel mutations. [PDF]

, 2017
Voltage-gated sodium channels are pore-forming transmembrane proteins that selectively allow sodium ions to flow across the plasma membrane according to the electro-chemical gradient thus mediating the rising phase of action potentials in excitable cells
Schaeffer, Mathieu, Urs Thomet, Hugues Abriel, Mathieu Schaeffer, Pascale Gaudet, Bairoch, Amos, Zahn-Zabal, Monique, Amos Bairoch, Zahn, Monique, Rougier, Jean-Sébastien, Britan, Aurore, Bairoch, Amos Marc, Abriel, Hugues, Aurore Britan, Thomet, Urs, Hinard, Valérie, Jean-Sébastien Rougier, Valérie Hinard, Gaudet, Pascale, Monique Zahn-Zabal   +19 more
core   +2 more sources

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy

Scientific Reports
Epilepsy affects millions of people globally, with approximately one-third of patients experiencing drug-resistant seizures. Developing new anti-epileptic drugs is time-intensive and costly, prompting interest in computational drug repositioning ...
Pawan Kumar, Vivek Kumar, Raveena Chauhan, Vandana Saini, Ajit Kumar   +4 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Bioinspired Mechanosensitive Organic Artificial Neuron With Programmable Excitatory and Inhibitory Responses via Nonlinear Mechano‐Electrochemical Coupling

Advanced Materials, EarlyView.
Organic artificial neurons couple mechanical deformation and ionic environments through nonlinear mechano‐electrochemical dynamics. Mechanical strain and electrolyte concentration reshape their nonlinear electrical characteristics, programming excitatory or inhibitory spiking responses that mimic mechanosensitive biological neurons and enable ...
Rassen Boukraa, Pietro Belleri, Zsolt M. Kovács‐Vajna, Paschalis Gkoupidenis, Fabrizio Torricelli   +4 more
wiley   +1 more source

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review

Journal of Cannabis Research
Background Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro, Sarah Eduarda Silva, Julio Cesar Moreira Brito, Alessandra Matavel   +3 more
doaj   +1 more source

Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension–associated genes

Biomolecules & Biomedicine
Coronary artery disease (CAD) represents a complex interplay of genetic, environmental, and lifestyle factors. In this study, we utilized whole-exome sequencing (WES) on 28 patients with obstructive CAD to identify rare variants that may influence ...
Mohammad Fahad Ullah, Rashid Mir, Jamsheed Javid, Imadeldin Elfaki, Faisal H. Altemani, Jameel Barnawi, Naseh A. Algehainy, Mohammed M. Jalal, Malik A. Altayar, Salem Owaid Albalawi, Syed Khalid Mustafa, Aadil Yousif, Eram Husain, Faris J. Tayeb, Faisel M. AbuDuhier   +14 more
doaj   +1 more source

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Nature Communications, 2016
Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when ...
Kevin Oelstrom, Baron Chanda
doaj   +1 more source