Results 91 to 100 of about 66,157 (301)

Kv7 and Kv11 channels in myometrial regulation.

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid, Greenwood, IA, Rachel M. Tribe, Greenwood, Iain, Iain A. Greenwood, Tribe, RM   +5 more
core   +1 more source

Second‐Harmonic Hyper‐Mie Optical Activity Enables Closed‐Loop Chiral Photochemistry

Advanced Materials, EarlyView.
Nonlinear chiral photochemistry is demonstrated in CdTe/CdO nanohelices, where circularly polarized infrared light both drives and tracks photo‐oxidation via second‐harmonic scattering. This closed‐loop process reveals real‐time structural evolution, including shell fracturing and core exposure, accompanied by a transition from hyper‐Mie to hyper ...
Hoyeon Choi, Kody Whisnant, Ben J. Olohan, E. Petronijevic, G. Dan Pantoș, Nicholas A. Kotov, Ventsislav K. Valev   +6 more
wiley   +1 more source

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review

Journal of Cannabis Research
Background Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro, Sarah Eduarda Silva, Julio Cesar Moreira Brito, Alessandra Matavel   +3 more
doaj   +1 more source

Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension–associated genes

Biomolecules & Biomedicine
Coronary artery disease (CAD) represents a complex interplay of genetic, environmental, and lifestyle factors. In this study, we utilized whole-exome sequencing (WES) on 28 patients with obstructive CAD to identify rare variants that may influence ...
Mohammad Fahad Ullah, Rashid Mir, Jamsheed Javid, Imadeldin Elfaki, Faisal H. Altemani, Jameel Barnawi, Naseh A. Algehainy, Mohammed M. Jalal, Malik A. Altayar, Salem Owaid Albalawi, Syed Khalid Mustafa, Aadil Yousif, Eram Husain, Faris J. Tayeb, Faisel M. AbuDuhier   +14 more
doaj   +1 more source

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Nature Communications, 2016
Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when ...
Kevin Oelstrom, Baron Chanda
doaj   +1 more source

Skeletal Muscle Na+ Channel Disorders

Frontiers in Pharmacology, 2011
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.
Dina eSimkin, Saïd eBendahhou
doaj   +1 more source

Voltage-gated sodium channels and metastatic disease [PDF]

Channels, 2012
Voltage-gated Na (+) channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in metastatic cells from a number of cancers. In these cells, Na (+) current carried by α subunits enhances migration, invasion and metastasis in vivo.
openaire   +4 more sources

Designable van der Waals Crystal for Artificial Neuronal Cell Mimicking

Advanced Materials, EarlyView.
Designable van der Waals crystal has been demonstrated for device‐scale neuronal cell mimicking. The structural similarity between ion‐channel in biological membranes and layered vdW lattices is realized with nano‐crystallization via Ar + H2S plasma sulfurization.
Jinhyoung Lee, Gunhyoung Kim, Dongho Lee, Seowoo Son, Hyunho Seok, Sihoon Son, Hyunbin Choi, Geonwook Kim, Geumji Back, Hyunkyu Kim, Chaerin Park, Junmin Ahn, Seongyun Je, Chaeyoung Im, Junil Cho, Magdalena Grzeszczyk, Seongho Kim, Eunseo Go, Hyunwoo Shim, Donghwan Choi, Muyoung Kim, Hyoeng‐U. Kim, Won‐Jun Jang, Taesung Kim   +23 more
wiley   +1 more source

Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state

, 2012
Background: Voltage-gated sodium channels dysregulation is important for hyperexcitability leading to pain persistence. Sodium channel blockers currently used to treat neuropathic pain are poorly tolerated.
Decosterd, Isabelle, Kirschmann, Guylène, Laedermann, Cedric J., Suter, Marc R., Abriel, Hugues   +4 more
core   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source