Results 231 to 240 of about 2,526,088 (292)

Scanning mutagenesis of the voltage-gated sodium channel Na_V1.2 using base editing. [PDF]

Cell Rep
Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL, Pan JQ.   +12 more
europepmc   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

V1848I Mutation in the Voltage-Gated Sodium Channel Confers High-Level Resistance to Indoxacarb and Metaflumizone in Spodoptera exigua. [PDF]

Insects
Liu X, Cao M, Mei W, Wang X, Wu Y.
europepmc   +1 more source

Anode‐Free Sodium Metal Batteries: From Materials Design to System‐Level Integration

Advanced Science, EarlyView.
Anode‐free sodium metal batteries hold no sodium reserve, so every inefficiency becomes permanent loss. Resolving the inventory into reversible, dead, and chemically bound fractions exposes what Coulombic efficiency hides. Practical 500‐cycle operation requires above 99.95%, a threshold few systems meet under lean electrolyte and high areal capacity ...
Hamid Hussain, Shazaib Ali, Muhammad Ali, Samia Aman, Moazzam Ali, Ufra Naseer, Sajid Farooq, Asif Mahmood, Sailing He, Yinzhu Jiang, Muhammad Yousaf   +10 more
wiley   +1 more source

Therapeutic targeting of voltage-gated sodium channel Na_V1.7 for cancer metastasis. [PDF]

Front Pharmacol
Pukkanasut P, Jaskula-Sztul R, Gomora JC, Velu SE.   +3 more
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

First detection of the S989P+V1016G+D1763Y haplotype and expansion of voltage-gated sodium channel mutations in Aedes aegypti in Taiwan in 2016-2023. [PDF]

PLoS Negl Trop Dis
Chung HH, Teng HJ, Huang CG, Tsai IJ, Chen HJ, Komagata O, Kasai S, Tsai KH, Chen SL.   +8 more
europepmc   +1 more source

New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias? [PDF]

Heart Rhythm
Williams ZJ, Payne LB, Wu X, Gourdie RG.
europepmc   +1 more source

Insights into the voltage-gated sodium channel, Na_V1.8, and its role in visceral pain perception. [PDF]

Front Pharmacol
Heinle JW, Dalessio S, Janicki P, Ouyang A, Vrana KE, Ruiz-Velasco V, Coates MD.   +6 more
europepmc   +1 more source

Correction: Molecular assessment of voltage-gated sodium channel (VGSC) gene mutations in Rhipicephalus microplus from Guangxi, China. [PDF]

Parasit Vectors
Jiang N, Xie T, Li C, Ma R, Gao A, Liu M, Wang S, Zhou Q, Wei X, Li J, Hu W, Feng X.   +11 more
europepmc   +1 more source