Interactions of pyrethroids with the voltage-gated sodium channel
Davies, T. G. E., Williamson, M. S.
core
Three-dimensional Quantitative Structure-activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Na<sub>v</sub>1.7 Inhibition for the Management of Neuropathic Pain. [PDF]
Sharma S, Rana P, Dhingra N, Kaur T.
europepmc +1 more source
Molecular assessment of voltage-gated sodium channel (VGSC) gene mutations in Rhipicephalus microplus from Guangxi, China. [PDF]
Jiang N +11 more
europepmc +1 more source
Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating
Hollingworth D +6 more
europepmc +1 more source
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Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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A tamoxifen receptor within a voltage-gated sodium channel [PDF]
Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized.
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Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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The pharmacology of voltage-gated sodium channel activators [PDF]
Toxins and venom components that target voltage-gated sodium (NaV) channels have evolved numerous times due to the importance of this class of ion channels in the normal physiological function of peripheral and central neurons as well as cardiac and skeletal muscle.
Irina Vetter +2 more
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Voltage-Gated Sodium Channels and Hyperalgesia
Annual Review of Pharmacology and Toxicology, 2004Physiological and pharmacological evidence both have demonstrated a critical role for voltage-gated sodium channels (VGSCs) in many types of chronic pain syndromes because these channels play a fundamental role in the excitability of neurons in the central and peripheral nervous systems. Alterations in function of these channels appear to be intimately
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