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Diversity of Mammalian Voltage‐Gated Sodium Channels
Annals of the New York Academy of Sciences, 1999ABSTRACT: A variety of different isoforms of mammalian voltage‐gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart.
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pH Modulation of Voltage-Gated Sodium Channels
2018Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations.
Colin H, Peters +3 more
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Toxins That Affect Voltage-Gated Sodium Channels
2017Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years of evolutions.
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Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
2017Benzothiazole is a versatile fused heterocycle that aroused much interest in drug discovery as anticonvulsant, neuroprotective, analgesic, anti-inflammatory, antimicrobial, and anticancer. Two benzothiazolamines, riluzole and lubeluzole, are known blockers of voltage-gated sodium (Nav) channels.
Farinato, Alessandro +2 more
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Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits
Channels, 2021Annette Nicke +2 more
exaly
Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel
Cell, 2019William A. Catterall +2 more
exaly