Results 171 to 180 of about 2,129,352 (275)

Domain- and state-specific shape of the electric field tunes voltage sensing in voltage-gated sodium channels. [PDF]

Biophys J, 2023
Kostritskii AY, Machtens JP.
europepmc   +1 more source

Photo‐Gated Corona Microfluidics

Advanced Science, EarlyView.
Photo‐gated corona microfluidics decouples optical programming from electric‐field actuation to enable reconfigurable manipulation on open, electrode‐pattern‐free surfaces. Near‐infrared irradiation locally melts paraffin, creating a reversible charge‐relaxation pathway that reconstructs the electric field.
Xiaxia Cui, Yiqing Liu, Xinyi Qiu, Manfei Liu, Biao Cheng, Yuan Zhou, Changguo Xue, Sheng Zhang, Xin Tang, Qiang Tang   +9 more
wiley   +1 more source

Modulation of Voltage-Gated Sodium Channels from Sensory Neurons by Isoeugenol. [PDF]

Int J Mol Sci
Ghim D, Dib J, Moreira-Junior L, Carvalho-de-Souza J.   +3 more
europepmc   +1 more source

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons. [PDF]

Cell Rep, 2023
Steiger LJ, Tsintsadze T, Mattheisen GB, Smith SM.   +3 more
europepmc   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Voltage-gated sodium channels: from roles and mechanisms in the metastatic cell behavior to clinical potential as therapeutic targets. [PDF]

Front Pharmacol, 2023
Sanchez-Sandoval AL, Hernández-Plata E, Gomora JC.   +2 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease. [PDF]

Rev Cardiovasc Med
Zhang XL, Wei TP, Yang F, Liu HH, Qian LL, Wang RX.   +5 more
europepmc   +1 more source

Voltage-Gated Sodium Channels [PDF]

, 2016
openaire   +2 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source