Results 81 to 90 of about 62,302 (192)

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J., M. J. Sutcliffe, Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Yuill, K. H., Ashmole, I., Yuill, K.H., Stansfeld, P.J., Stansfeld, Phillip J., I. Ashmole, P. J. Stansfeld, K. H. Yuill, P. R. Stanfield, Stanfield, P.R.   +14 more
core   +1 more source

Imaging large cohorts of single ion channels and their activity [PDF]

, 2013
As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance.
Euan R. Brown, Katia eHiersemenzel, Brown, Euan R; id_orcid, Katia Hiersemenzel, Rory R. Duncan, Duncan, Rory R, Hiersemenzel, Katia, Rory R Duncan, Euan R Brown   +8 more
core   +1 more source

Molecular and functional characterization of voltage-gated sodium channels in human sperm

Reproductive Biology and Endocrinology, 2009
Background We have investigated the expression of voltage-gated sodium channels in human spermatozoa and characterized their role in sperm motility. Methods Freshly ejaculated semen was collected from thirty normozoospermic human donors, with each donor ...
Cejudo-Román Antonio, Gallardo-Castro Manuel, Fernández-Sánchez Manuel, Ravina Cristina G, Pinto Francisco M, Candenas Luz   +5 more
doaj   +1 more source

Voltage-gated sodium channels assemble and gate as dimers

Nature Communications, 2017
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this ...
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes   +9 more
doaj   +1 more source

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
doaj   +1 more source

Noncanonical Roles of Voltage-Gated Sodium Channels

Neuron, 2013
The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience. Sodium channels Nav1.1-Nav1.3 and Nav1.6-Nav1.9 support electrogenesis in neurons and are often considered "neuronal," whereas Nav1.4 and Nav1.5 drive electrogenesis in skeletal and cardiac muscle.
Black, Joel A., Waxman, Stephen G.
openaire   +2 more sources

Nedd4-2 (NEDD4L) controls intracellular Na(+) -mediated activity of voltage-gated sodium channels in primary cortical neurons

, 2014
Nedd4-2, a HECT (homologous with E6-associated protein C-terminus)-type ubiquitin protein ligase, has been implicated in regulating several ion channels, including Navs (voltage-gated sodium channels).
Ekberg, J., Poronnik, Philp, Rychkov, G., Poronnik, P., Boase, Natasha A, Kumar, Sharad, Rychkov, Grigori, Ekberg, Jenny A, Manning, Jantina, Kumar, S., Boase, N., Manning, J.   +11 more
core   +1 more source

Behavioral/Systems/Cognitive

, 2008
nuates the amplitude of quantal synaptic voltages. These results demonstrate that Na amplify the synaptic voltage, enhancing the SNR and contrast sensitivity.
Narender K. Dhingra, Robert G. Smith, Michael A. Freed, Voltage-Gated Sodium Channels   +3 more
core  

Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin

Nature Communications
The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels.
Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall   +8 more
doaj   +1 more source