Results 31 to 40 of about 2,129,352 (275)

The crystal structure of a voltage-gated sodium channel [PDF]

Nature, 2011
Voltage-gated sodium (Na(V)) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (
Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.   +3 more
openaire   +2 more sources

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez, Héctor Castro, Isabel Arenas, David E. García, Ricardo González-Muñoz, Roberto Arreguín-Espinosa   +5 more
doaj   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging

Scientific Reports, 2023
Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang, Patricia M. Dijkman, Simon A. Wiessing, Misha Kudryashev   +3 more
doaj   +1 more source

Voltage‐gated Sodium Channels in Epilepsy [PDF]

Epilepsia, 2002
Summary: Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage‐gated sodium channels. This review summarizes recent data on changes of
openaire   +2 more sources

Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics

Frontiers in Cellular Neuroscience, 2018
Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog, Tal Barkai, Angelika Lampert, Alon Korngreen, Alon Korngreen   +4 more
doaj   +1 more source

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Molecular Brain, 2020
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 million adults in the United States ...
Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka, Rajesh Khanna   +9 more
doaj   +1 more source

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels

Marine Drugs, 2022
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior, Rimma Kalina, Irina Gladkikh, Elena Leychenko, Jan Tytgat, Steve Peigneur   +5 more
doaj   +1 more source

Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]

, 2014
Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
core   +1 more source