Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
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Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics
BiomedicinesVoltage-gated sodium channels (VGSCs) play pivotal roles in cellular function, particularly in the regulation of electrical signaling. Structural defects in these channels cause deleterious effects in a myriad of cell types, leading to various diseases ...
Angela Gyamfi +4 more
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Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
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Voltage‐gated Sodium Channels in Epilepsy [PDF]
Epilepsia, 2002 Summary: Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage‐gated sodium channels. This review summarizes recent data on changes of
openaire +2 more sources
Marine Toxins That Target Voltage-gated Sodium Channels
Marine Drugs, 2006 : Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which underlie generation and propagation of rapid electrical signals in nerve, muscle and heart. Nine different NaV receptor sites, for natural ligands and/or drugs, have been
Robert J. French +3 more
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Strategies for studying permeation at voltage-gated ion channels [PDF]
, 1991 Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
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Ion channel gradients in the apical tuft region of CA1 pyramidal neurons. [PDF]
PLoS ONE, 2012 Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally important for synaptic integration and plasticity. In the hippocampal region CA1, somato-dendritic gradients of AMPA receptors and the hyperpolarization-activated
Katie C Bittner +2 more
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Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]
, 2019 As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M +2 more
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The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells [PDF]
, 2007 Upregulation of functional voltage-gated Na+ channels (VGSCs) occurs in metastatic human breast cancer (BCa) in vitro and in vivo. The present study aimed to ascertain the specific involvement of the 'neonatal' splice variant of Nav1.5 (nNav1.5), thought
Brackenbury, William J. +3 more
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The envenomation of general physiology throughout the last century. [PDF]
, 2017 Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
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