Results 21 to 30 of about 2,129,352 (275)

Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions [PDF]

Neural Regeneration Research
Voltage-gated sodium channels are essential ionic-conductance pathways in the nervous system, which play an irreplaceable role in modulating neuronal excitability and signal transduction.
Ni Li, Lin Yan, Anna Peng, Xuefei Fu, Huan Qin, Kai Yao   +5 more
doaj   +2 more sources

Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy [PDF]

Neurobiology of Disease
Summary: Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels.
Nicholas Denomme, Samantha L. Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M. Ziobro, Joe Minton, Chunling Chen, Yan Chen, Jacob M. Hull, James Offord, Alan V. Smrcka, Lori L. Isom   +11 more
doaj   +2 more sources

Inhibition of Voltage-Gated Sodium Channels by Animal Toxins [PDF]

Structural Dynamics
Voltage-gated sodium channels (NaVs) play important roles in propagating action potentials and their structure and function can be modulated by a variety of factors, including animal toxins.
Shane Gonen
doaj   +2 more sources

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies

Frontiers in Pharmacology, 2012
Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti, Michael eGollob, Dawood eDarbar   +2 more
doaj   +3 more sources

Drug binding sites on Nat1.8 sodium channels [PDF]

, 2008
The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core   +6 more sources

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
doaj   +3 more sources

Structure and function of potassium and calcium channels [PDF]

, 2005
In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core   +7 more sources

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites

Frontiers in Pharmacology, 2022
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri, Tamer M. Gamal El-Din   +1 more
doaj   +1 more source

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Nomenclature of Voltage-Gated Sodium Channels [PDF]

Neuron, 2000
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L., Barchi, Robert L., Caldwell, John H., Hofmann, Franz, Howe, James R., Hunter, John C., Kallen, Roland G., Mandel, Gail, Meisler, Miriam H., Netter, Yoheved Berwald, Noda, Masahara, Tamkun, Michael M., Waxman, Steven G., Wood, John N., Catterall, William A.   +14 more
openaire   +2 more sources