Results 31 to 40 of about 62,302 (192)
Shellfish Toxins Targeting Voltage-Gated Sodium Channels
Marine Drugs, 2013 Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable neurons and other cells and are targeted by commonly used local anesthetics, antiarrhythmics, and anticonvulsants. They are also
Fan Zhang +3 more
doaj +1 more source
Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes. [PDF]
PLoS ONE, 2016 The ability of azobenzene trimethylammonium bromide (azoTAB) to sensitize cardiac tissue excitability to light was recently reported. The dark, thermally relaxed trans- isomer of azoTAB suppressed spontaneous activity and excitation propagation speed ...
Sheyda R Frolova +4 more
doaj +1 more source
Voltage-gated sodium channels as targets for pyrethroid insecticides [PDF]
, 2017 The pyrethroid insecticides are a very successful group of compounds that have been used extensively for the control of arthropod pests of agricultural crops and vectors of animal and human disease.
Field, L.M. +14 more
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Light-Induced Control of Voltage Gated Ion Channels
, 2022 Voltage gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. They are key targets in receptor pharmacology, since the simple actions of opening and closing their pore with ...
Shirin, Faraji +3 more
core +1 more source
Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome [PDF]
Jichu yixue yu linchuang, 2020 Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS).
LAN Fei, LIU Tai-yang, YANG Jie
doaj
Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan +3 more
core +1 more source
Molecular Pain, 2011 Neuropathic pain is a common clinical condition. Current treatments are often inadequate, ineffective, or produce potentially severe adverse effects. Understanding the mechanisms that underlie the development and maintenance of neuropathic pain will be ...
Li Yun-Qing +3 more
doaj +1 more source
Kv7 and Kv11 channels in myometrial regulation.
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +1 more source
Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
doaj +1 more source
The pharmacology of voltage-gated sodium channel activators [PDF]
Neuropharmacology, 2017 Toxins and venom components that target voltage-gated sodium (NaV) channels have evolved numerous times due to the importance of this class of ion channels in the normal physiological function of peripheral and central neurons as well as cardiac and skeletal muscle.
Jennifer R. Deuis +3 more
openaire +4 more sources