Results 71 to 80 of about 62,302 (192)

Voltage-gated sodium channels and metastatic disease [PDF]

Channels, 2012
Voltage-gated Na (+) channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in metastatic cells from a number of cancers. In these cells, Na (+) current carried by α subunits enhances migration, invasion and metastasis in vivo.
openaire   +4 more sources

Alzheimer's secretases regulate voltage-gated sodium channels

, 2010
BACE1 and presenilin (PS)/γ-secretase are primary proteolytic enzymes responsible for the generation of pathogenic amyloid β-peptides (Aβ) in Alzheimer's disease. We and others have found that β-subunits of the voltage-gated sodium channel (Na(v)βs) also
Gersbacher, M T, Doo Yeon Kim, Dora M. Kovacs, Kim, D Y, Kovacs, D M, Manuel T. Gersbacher   +5 more
core   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Onwuli, Donatus O., Donatus O. Onwuli, Beltran-Alvarez, Pedro, Pedro Beltran-Alvarez   +3 more
core   +1 more source

Voltage-gated sodium channels dysfunction in depression: the hypothesis

Psychiatry and Behavioral Sciences, 2016
Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions including neuronal signalling, muscle ...
Osman Ozdemir
doaj   +1 more source

Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex

Frontiers in Molecular Neuroscience
Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt, Roy E. Strowd III, Kimberly F. Raab-Graham   +2 more
doaj   +1 more source

Investigations on subunit-specific assembly and structure-function studies of the voltage sensor in KCNQ potassium channels

, 2007
A detailed understanding of how potassium channels function is crucial e. g. for the development of drugs, which could lead to novel therapeutic concepts for diseases ranging from diabetes to cardiac abnormalities.
Athanasiadu, Despina, Athanasiadu, D.
core  

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Frontiers in Pharmacology, 2010
Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches.
Dao W Wang, Dao W Wang, Akshitkumar M Mistry, Kristopher M Kahlig, Jennifer A Kearney, Jizhou eXiang, Alfred L George, Alfred L George   +7 more
doaj   +1 more source

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Channels
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy   +5 more
doaj   +1 more source

A comparative study of voltage-gated sodium channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species

, 2007
We report the complete cDNA sequence of the Anopheles gambiae voltage-gated sodium channel (VGSC) a subunit isolated from mature adult mosquitoes. The genomic DNA contains 35 deduced exons with a predicted translation of
Field, L. M., Davies, T. G. E., Usherwood, P. N. R., Williamson, M. S.   +3 more
core   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core   +1 more source