Results 11 to 20 of about 56,373 (210)

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Voltage-gated sodium channels gene expression in Burning Mouth Syndrome: a case-control study

Brazilian Oral Research, 2023
Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa, despite the absence of any clinical signs. Its etiology is unknown, and there is still no effective treatment to date.
Carina DOMANESCHI, Vanessa Juliana Gomes CARVALHO, Bruno Munhoz MAROTTA, Norberto Nobuo SUGAYA, Fábio Daumas NUNES, Camila de Barros GALLO   +5 more
doaj   +1 more source

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez, Héctor Castro, Isabel Arenas, David E. García, Ricardo González-Muñoz, Roberto Arreguín-Espinosa   +5 more
doaj   +1 more source

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

Frontiers in Physiology, 2015
Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH, Hugues eAbriel   +1 more
doaj   +1 more source

Cannabidiol interactions with voltage-gated sodium channels

eLife, 2020
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, BA Wallace   +5 more
doaj   +1 more source

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging

Scientific Reports, 2023
Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang, Patricia M. Dijkman, Simon A. Wiessing, Misha Kudryashev   +3 more
doaj   +1 more source

Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics

Frontiers in Cellular Neuroscience, 2018
Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog, Tal Barkai, Angelika Lampert, Alon Korngreen, Alon Korngreen   +4 more
doaj   +1 more source

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels

Marine Drugs, 2022
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior, Rimma Kalina, Irina Gladkikh, Elena Leychenko, Jan Tytgat, Steve Peigneur   +5 more
doaj   +1 more source

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Molecular Brain, 2020
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 million adults in the United States ...
Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka, Rajesh Khanna   +9 more
doaj   +1 more source