CONTRIBUTIONS OF INTRACELLULAR IONS TO Kv CHANNEL VOLTAGE SENSOR DYNAMICS. [PDF]
Frontiers in Pharmacology, 2012 Voltage sensing domains of Kv channels control ionic conductance through coupling of the movement of charged residues in the S4 segment to conformational changes at the cytoplasmic region of the pore domain, that allow K+ ions to flow.
Samuel eGoodchild, David eFedida
doaj +2 more sources
Voltage sensor inactivation in potassium channels [PDF]
Frontiers in Pharmacology, 2012 In voltage-gated potassium (Kv) channels membrane depolarization causes movement of a voltage sensor domain. This conformational change of the protein is transmitted to the pore domain and eventually leads to pore opening.
Robert eBähring +3 more
doaj +3 more sources
Research and Experiments on a Unipolar Capacitive Voltage Sensor
Sensors, 2015 Voltage sensors are an important part of the electric system. In service, traditional voltage sensors need to directly contact a high-voltage charged body. Sensors involve a large volume, complex insulation structures, and high design costs. Typically an
Qiang Zhou +3 more
doaj +2 more sources
A Voltage-Sensor Water Pore [PDF]
Biophysical Journal, 2006 Voltage-sensor (VS) domains cause the pore of voltage-gated ion channels to open and close in response to changes in transmembrane potential. Recent experimental studies suggest that VS domains are independent structural units. This independence is revealed dramatically by a voltage-dependent proton-selective channel (Hv), which has a sequence ...
Freites, J Alfredo +2 more
openaire +5 more sources
A CMOS Threshold Voltage Monitoring Sensor [PDF]
2023 12th International Conference on Modern Circuits and Systems Technologies (MOCAST), 2023 A real-time CMOS threshold voltage (VTH) monitoring sensor is presented. A threshold-voltage extractor architecture with a nested feedback loop technique is exploited, to provide input-free operation. The topology presents high immunity to supply voltage variations and self-compensation for second-order effects.
Konstantinos Moustakas +4 more
openaire +3 more sources
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation. [PDF]
J Gen Physiol, 2023 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to the rhythmic firing of pacemaker neurons and cardiomyocytes. Mutations in HCN channels are associated with cardiac arrhythmia and epilepsy.
Wu X +4 more
europepmc +2 more sources
Barium senses subtle pore changes in a voltage-gated K<sup>+</sup> channel associated with voltage sensor states and regulatory subunits. [PDF]
Sci AdvHuang L +12 more
europepmc +2 more sources
Electro-Mechanical Uncoupling of K<sub>V</sub>7.1 Voltage Sensor and Pore by 1,4-Benzodiazepines Is Modulated by Decoration of Position 1. [PDF]
Arch Pharm (Weinheim)Roßner F +5 more
europepmc +2 more sources
Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are critical molecular determinants of action potential generation and propagation in excitable cells. Normal NaV channel function disruption can affect physiological neuronal signaling and lead to increased ...
Phuong T. Nguyen +2 more
doaj +1 more source
Optimization of voltage doublers for energy harvesting applications [PDF]
, 2013 Energy harvesting is increasingly enabling the expansion of wireless sensor networks in challenging applications by replacing batteries in low power sensors. Many forms of energy harvester suffer from low output voltage which can be partially compensated
Judd, Martin, Roscoe, Nina
core +3 more sources