Results 41 to 50 of about 212,775 (379)

Pregnancy and delivery in women with von Willebrand’s disease and different von Willebrand factor mutations

Haematologica, 2010
Background Pregnancy in von Willebrand’s disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty.Design ...
Giancarlo Castaman, Alberto Tosetto, Francesco Rodeghiero   +2 more
doaj   +1 more source

Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.

New England Journal of Medicine, 1998
BACKGROUND Thrombotic thrombocytopenic purpura is a potentially fatal disease characterized by widespread platelet thrombi in the microcirculation. In the normal circulation, von Willebrand factor is cleaved by a plasma protease.
H. Tsai, E. Lian
semanticscholar   +1 more source

Desmopressin in moderate hemophilia a patients: A treatment worth considering [PDF]

, 2018
Desmopressin increases endogenous factor VIII levels in hemophilia A. Large inter-individual variation in the response to desmopressin is observed.
Beckers, E., Bom, J.G. van der, Carcao, M., Fijnvandraat, K., Jackson, S., Kruip, M.J.H.A., Loomans, J.I., Peters, M., Platokouki, H., RISE Consortium, Santagostino, E., Velzen, A.S. van, Voorberg, J.   +12 more
core   +3 more sources

Insights into pathological mechanisms of missense mutations in C-terminal domains of von Willebrand factor causing qualitative or quantitative von Willebrand disease

Haematologica, 2013
The carboxyl-terminal domains of von Willebrand factor, D4-CK, are cysteine-rich implying that they are structurally important. In this study we characterized the impact of five cysteine missense mutations residing in D4-CK domains on the conformation ...
Hamideh Yadegari, Julia Driesen, Anna Pavlova, Arijit Biswas, Vytautas Ivaskevicius, Robert Klamroth, Johannes Oldenburg   +6 more
doaj   +1 more source

von Willebrand factor activity and activated partial thromboplastin time as proxy biomarkers for coagulopathies in women with menorrhagia in Zambia: a case-control study

The Pan African Medical Journal, 2021
INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje, Trevor Kaile, Sumbukeni Kowa, Musalula Sinkala, Marah Simakando, Jacob Ndhlovu, Brian Chanda Chiluba   +6 more
doaj   +1 more source

The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.

Blood, 2019
D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides ...
Xianchi Dong, N. Leksa, E. S. Chhabra, J. Arndt, Qi Lu, K. Knockenhauer, R. Peters, T. Springer   +7 more
semanticscholar   +1 more source

Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]

, 2009
Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor, Cervenak, László, Förhécz, Zsolt, Gombos, Tímea, Hársfalvi, Jolán, Jánoskuti, Lívia, Kunde, Jan, Makó, Veronika, Papassotiriou, Jana, Pozsonyi, Zoltán, Prohászka, Zoltán   +10 more
core   +1 more source

High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor

Journal of Thrombosis and Haemostasis, 2018
Essentials Elevated procoagulant levels are associated with an increased risk of venous thrombosis (VT). The dependency on concurrent increased factor levels and VT was analyzed in a large study.
I. M. Rietveld, W. Lijfering, S. Cessie, M. Bos, F. Rosendaal, P. Reitsma, S. Cannegieter   +6 more
semanticscholar   +1 more source

Recombinant von Willebrand Factor for Pediatric Patient with von Willebrand Disease: First Report in Korea

Clinical Pediatric Hematology-Oncology, 2021
von Willebrand disease (VWD) is the most common hereditary bleeding disorder. The treatment of VWD consists mainly of desmopressin and plasma-derived von Willebrand factor (pd-VWF) concentrate.
Seoin Kim, Young Shil Park
doaj   +1 more source

Successful management of severe refractory acquired immune bleeding disorder: Prior to insisting surgery [PDF]

, 2014
INTRODUCTIONAcquired bleeding disorders are rare and may be missed before surgery. Additionally, they may be refractory to conventional treatments.PRESENTATION OF CASEA 50-year-old patient experienced prolonged post-operative bleeding when his bleeding ...
Al-Barjas, H., Al-Jafar, Hassan, AlSaeed, Ahmad M., Hashem, Raed A., Refaii, Thanaa M.K.   +4 more
core   +3 more sources