Results 41 to 50 of about 214,027 (378)

von Willebrand factor activity and activated partial thromboplastin time as proxy biomarkers for coagulopathies in women with menorrhagia in Zambia: a case-control study

The Pan African Medical Journal, 2021
INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje, Trevor Kaile, Sumbukeni Kowa, Musalula Sinkala, Marah Simakando, Jacob Ndhlovu, Brian Chanda Chiluba   +6 more
doaj   +1 more source

The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.

Blood, 2019
D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides ...
Xianchi Dong, N. Leksa, E. S. Chhabra, J. Arndt, Qi Lu, K. Knockenhauer, R. Peters, T. Springer   +7 more
semanticscholar   +1 more source

High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor

Journal of Thrombosis and Haemostasis, 2018
Essentials Elevated procoagulant levels are associated with an increased risk of venous thrombosis (VT). The dependency on concurrent increased factor levels and VT was analyzed in a large study.
I. M. Rietveld, W. Lijfering, S. Cessie, M. Bos, F. Rosendaal, P. Reitsma, S. Cannegieter   +6 more
semanticscholar   +1 more source

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]

, 2009
The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás, Cervenak, László, Derzsy, Zoltán, Gombos, Tímea, Hársfalvi, Jolán, Makó, Veronika, Molvarec, Attila, Prohászka, Zoltán, Rigó, János, Udvardy, Miklós László   +9 more
core   +1 more source

Recombinant von Willebrand Factor for Pediatric Patient with von Willebrand Disease: First Report in Korea

Clinical Pediatric Hematology-Oncology, 2021
von Willebrand disease (VWD) is the most common hereditary bleeding disorder. The treatment of VWD consists mainly of desmopressin and plasma-derived von Willebrand factor (pd-VWF) concentrate.
Seoin Kim, Young Shil Park
doaj   +1 more source

The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

Mediators of Inflammation, 2017
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and ...
F. Gragnano, S. Sperlongano, E. Golia, F. Natale, R. Bianchi, M. Crisci, F. Fimiani, I. Pariggiano, V. Diana, A. Carbone, A. Cesaro, C. Concilio, G. Limongelli, M. Russo, P. Calabrò   +14 more
semanticscholar   +1 more source

von Willebrand Disease: The diagnosis and management of this bleeding disorder

Medical Journal of Babylon, 2020
von Willebrand disease (vWD) is one of the most common bleeding disorders, first described by Erik von Willebrand in the Aland Islands. It occurs as a result of decreased or abnormal von Willebrand factor (vWF), a factor that is needed in the process of ...
Basim A. Abd, Nawrass J Al-Salihi
doaj   +1 more source

Significant gynecological bleeding in women with low von Willebrand factor levels.

Blood Advances, 2018
Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions.
M. Lavin, S. Águila, Niall Dalton, Margaret Nolan, M. Byrne, K. Ryan, B. White, N. O'Connell, J. O’Sullivan, J. Di Paola, P. James, J. O’Donnell   +11 more
semanticscholar   +1 more source

Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking

Haematologica, 2017
Factor VIII C-domains are believed to have specific functions in cofactor activity and in interactions with von Willebrand factor. We have previously shown that factor VIII is co-targeted with von Willebrand factor to the Weibel-Palade bodies in blood ...
Eduard H.T.M. Ebberink, Eveline A.M. Bouwens, Esther Bloem, Mariëtte Boon-Spijker, Maartje van den Biggelaar, Jan Voorberg, Alexander B. Meijer, Koen Mertens   +7 more
doaj   +1 more source

Desmopressin in moderate hemophilia a patients: A treatment worth considering [PDF]

, 2018
Desmopressin increases endogenous factor VIII levels in hemophilia A. Large inter-individual variation in the response to desmopressin is observed.
Beckers, E., Bom, J.G. van der, Carcao, M., Fijnvandraat, K., Jackson, S., Kruip, M.J.H.A., Loomans, J.I., Peters, M., Platokouki, H., RISE Consortium, Santagostino, E., Velzen, A.S. van, Voorberg, J.   +12 more
core   +4 more sources