Results 91 to 100 of about 49,526 (230)

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure [PDF]

, 2016
In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.
Ishikawa, Makoto, Izumi, Yukitoshi, Yoshitomi, Takeshi, Zorumski, Charles F   +3 more
core   +3 more sources

The Safety, Toleration, and Pharmacokinetics of Two Intravenous Voriconazole Formulations in Healthy Chinese Volunteers After Increasing Dose Administrations [PDF]

, 2022
Gang Chen, Zejuan Wang, Xiaona Liu, Yanan Zhang, Min Li, Aihua Du, Haiqing Zhen, Xiaolin Wang, Dan Zhang, Mengke Zhang, Siqi Zang, Lina Zhang, Huiting Zhu, Jin Wang   +13 more
openalex   +1 more source

Enhancing voriconazole therapy in liver dysfunction: exploring administration schemes and predictive factors for trough concentration and efficacy

Frontiers in Pharmacology
Introduction: The application of voriconazole in patients with liver dysfunction lacks pharmacokinetic data. In previous study, we proposed to develop voriconazole dosing regimens for these patients according to their total bilirubin, but the regimens ...
Yichang Zhao, Yichang Zhao, Huaiyuan Liu, Huaiyuan Liu, Chenlin Xiao, Chenlin Xiao, Jingjing Hou, Jingjing Hou, Bikui Zhang, Bikui Zhang, Jiakai Li, Jiakai Li, Min Zhang, Yongfang Jiang, Indy Sandaradura, Indy Sandaradura, Xuansheng Ding, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

Frontiers in Microbiology, 2020
In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α-demethylase.
Jasper Elvin James, Erwin Lamping, Jacinta Santhanam, Trudy Jane Milne, Mohd Fuat Abd Razak, Latiffah Zakaria, Richard David Cannon   +6 more
doaj   +1 more source

Voriconazole is a safe and effective anti-fungal prophylactic agent during induction therapy of acute myeloid leukemia

Indian Journal of Medical and Paediatric Oncology, 2016
Background: Antifungal prophylaxis (AFP) reduces the incidence of invasive fungal infections (IFIs) during induction therapy of acute myeloid leukemia (AML). Posaconazole is considered the standard of care.
Akash Shah, Prasanth Ganesan, Venkatraman Radhakrishnan, Krishnarathinam Kannan, Rejiv Rajendranath, Vandana Mahajan, Varalakshmi Vijayakumar, Trivadi Ganesan, Tenali Gnana Sagar   +8 more
doaj   +1 more source

Characteristics of voriconazole-induced visual disturbances and hallucinations: case reports and literature review

Frontiers in Pharmacology
Voriconazole, a broad-spectrum antifungal agent, is considered the first-line treatment for invasive aspergillosis. In this article, we report three cases of patients who experienced visual disturbances and hallucinations following voriconazole therapy ...
Ya Liu, Ying Huang, Xiang Liu, Danxia Wang, Yixiang Hu   +4 more
doaj   +1 more source

Hyperlipidemia Caused by Voriconazole: A Case Report

Infection and Drug Resistance, 2021
Jiasheng Wu,1,2,* Na Chen,3,* Yake Yao,1 Jianying Zhou,1 Hua Zhou1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People’s Republic of China;
Wu J, Chen N, Yao Y, Zhou J, Zhou H
doaj  

Institutional Experience with Voriconazole Compared with Liposomal Amphotericin B as Empiric Therapy for Febrile Neutropenia [PDF]

, 2007
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90034/1/phco.27.7.970 ...
Boogaerts M, Cagnoni PJ, Curtis D Collins, Daryl D DePestel, Donowitz GR, Emily R Mackler, Harry P Erba, Hoban DJ, Jorgensen KJ, Kappe R, Kathleen Welch, Klastersky J, Nadine Shehab   +12 more
core   +1 more source

Disposition of voriconazole during continuous veno-venous haemodiafiltration (CVVHDF) in a single patient [PDF]

, 2017
Objectives: To determine whether voriconazole dosage adjustment is required during continuous veno-venous haemodiafiltration (CVVHDF). Methods: Voriconazole pharmacokinetics were studied in a critically ill patient under CVVHDF.
Buclin, T., Liaudet, L., Marchetti, O., Padoin, C., Robatel, C., Rusca, M.   +5 more
core  

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) [PDF]

, 2015
Herein, we have investigated the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic ...
Andrew G. S. Warrilow, David C. Lamb, Diane E. Kelly, Josie E. Parker, Nicola J. Rolley, Stephen N. Smith, Steven L. Kelly, W. David Nes   +7 more
core   +1 more source