Results 11 to 20 of about 39,685 (269)

Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.

PLoS Pathogens, 2020
VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses.
Pathum Ekanayaka, Seo-Yong Lee, Thilina U B Herath, Jae-Hoon Kim, Tae-Hwan Kim, Hyuncheol Lee, Kiramage Chathuranga, W A Gayan Chathuranga, Jong-Hyeon Park, Jong-Soo Lee   +9 more
doaj   +4 more sources

Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

npj Vaccines, 2021
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with a high mortality rate, while Merkel cell polyomavirus (MCV) has been pointed as the causative agent of MCC. A better prognosis of MCC associated with a high level of antibodies against
Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang   +5 more
doaj   +2 more sources

Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells

Virology Journal, 2019
Background VP1 of the chicken anemia virus (CAV) is a structural protein that is required for virus encapsulation. VP1 proteins are present both in the nucleus and cytoplasm; however, the functional nuclear localization signal (NLS) and nuclear export ...
Jai-Hong Cheng, Guan-Hua Lai, Yi-Yang Lien, Fang-Chun Sun, Shan-Ling Hsu, Pei-Chin Chuang, Meng-Shiou Lee   +6 more
doaj   +2 more sources

Characterization of the DNA binding activity of structural protein VP1 from chicken anaemia virus

BMC Veterinary Research, 2018
Background Chicken anaemia virus (CAV) is commonly found in poultry. VP1 is the sole structural protein of CAV, which is the major component responsible for capsid assembly. The CAV virion consists of the VP1 protein and a viral genome. However, there is
Guan-Hua Lai, Ming-Kuem Lin, Yi-Yang Lien, Jai-Hong Cheng, Fang-Chun Sun, Meng-Shiunn Lee, Hsi-Jien Chen, Meng-Shiou Lee   +7 more
doaj   +2 more sources

The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model. [PDF]

PLoS Pathogens, 2015
Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein ligand-1 (PSGL-1) as an EV71 receptor and found that an amino acid residue 145 in the
Chikako Kataoka, Tadaki Suzuki, Osamu Kotani, Naoko Iwata-Yoshikawa, Noriyo Nagata, Yasushi Ami, Takaji Wakita, Yorihiro Nishimura, Hiroyuki Shimizu   +8 more
doaj   +2 more sources

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

Investigative Ophthalmology and Visual Science, 2019
Purpose We previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Kathleen S. Molnar, Bryan M. Dunyak, Bonnie G. Su, Yevgeniy Izrayelit, Brittney N McGlasson-Naumann, P. Hamilton, M. Qian, D. Covey, J. Gestwicki, L. Makley, U. Andley   +10 more
semanticscholar   +3 more sources

Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1.

PLoS ONE, 2015
Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV).
Miao Wang, Li Pan, Peng Zhou, Jianliang Lv, Zhongwang Zhang, Yonglu Wang, Yongguang Zhang   +6 more
doaj   +2 more sources

Identification of a conserved B-cell epitope on duck hepatitis A type 1 virus VP1 protein.

PLoS ONE, 2015
BackgroundThe VP1 protein of duck hepatitis A virus (DHAV) is a major structural protein that induces neutralizing antibodies in ducks; however, B-cell epitopes on the VP1 protein of duck hepatitis A genotype 1 virus (DHAV-1) have not been characterized ...
Xiaoying Wu, Xiaojun Li, Qingshan Zhang, Shaozhou Wulin, Xiaofei Bai, Tingting Zhang, Yue Wang, Ming Liu, Yun Zhang   +8 more
doaj   +2 more sources

PRMT5 Facilitates Infectious Bursal Disease Virus Replication through Arginine Methylation of VP1

Journal of Virology, 2023
Post-translational modification of infectious bursal disease virus (IBDV) VP1 is important for the regulation of its polymerase activity. Investigation of the significance of specific modification of VP1 can lead to better understanding of viral ...
Xifeng Hu, Zheng Chen, Xiangdong Wu, Qiuling Fu, Z. Chen, Yu Huang, Huansheng Wu   +6 more
semanticscholar   +1 more source

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Journal of Experimental Medicine, 2020
Bodda et al. show that the deubiquitinase activity of the HSV1 VP1-2 protein inhibits induction of type I interferon in the brain. This is mediated through deubiquitination of the signaling protein STING, thus preventing activation of host defense after ...
C. Bodda, L. Reinert, Stefanie Fruhwürth, Timmy Richardo, Chenglong Sun, Bao-cun Zhang, M. Kalamvoki, Anja Pohlmann, T. Mogensen, P. Bergström, Lotta Agholme, P. O’Hare, B. Sodeik, M. Gyrd-Hansen, H. Zetterberg, S. Paludan   +15 more
semanticscholar   +1 more source