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The Baculovirus Expression System Expresses Chimeric RHDV VLPs as Bivalent Vaccine Candidates for Classic RHDV (GI.1) and RHDV2 (GI.2) [PDF]

Vaccines
Background: Rabbit hemorrhagic disease (RHD) is an acute, hemorrhagic and highly lethal infectious disease caused by rabbit hemorrhagic disease virus (RHDV), which causes huge economic losses to the rabbit breeding industry.
Yan Wang, Yiyang Fan, Ruixiang Bi, Yapeng Zhao, Wanning Gao, Derong Zhang, Jialin Bai   +6 more
doaj   +2 more sources

Phylogenetic Analysis of European Brown Hare Syndrome Virus Strains from Poland (1992–2004) [PDF]

Viruses, 2021
European brown hare syndrome (EBHS) is lethal to several species of free-living hares worldwide. The genetic characterization of its virus (EBHSV) strains in European circulation and epidemiological knowledge of EBHSV infections is not yet complete.
Andrzej Fitzner, Ewa Kwit, Wiesław Niedbalski, Ewelina Bigoraj, Andrzej Kęsy, Artur Rzeżutka   +5 more
doaj   +2 more sources

Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988–2021 [PDF]

Viruses, 2023
Rabbit haemorrhagic disease virus (RHDV), European brown hare syndrome virus (EBHSV), rabbit calicivirus (RCV), and hare calicivirus (HaCV) belong to the genus Lagovirus of the Caliciviridae family that causes severe diseases in rabbits and several hare (
Pir Tariq Shah, Amina Nawal Bahoussi, Caiting Yang, Guanhan Yao, Li Dong, Changxin Wu, Li Xing   +6 more
doaj   +2 more sources

Epitope mapping of a neutralizing antibody against rabbit hemorrhagic disease virus GI.2 [PDF]

Veterinary Research
In 2010, rabbit hemorrhagic disease virus (RHDV) GI.2 emerged, and unlike RHDV GI.1, it caused mortality in young rabbits, while existing vaccines were not fully protective.
Ana Podadera, Mila Leuthold, José Manuel Martín-Alonso, Rosa Casais, Angel Luis Álvarez, M. J. Lobo-Castañón, Francisco Parra, Kevin Paul Dalton   +7 more
doaj   +2 more sources

Virus-like Particles Produced in the Baculovirus System Protect Hares from European Brown Hare Syndrome Virus (EBHSV) Infection [PDF]

Vaccines
Background/Objectives: European Brown Hare Syndrome (EBHS) is an acute and highly contagious viral disease of hares that causes considerable economic losses on wild and captive-reared hares.
Giulio Severi, Lucia Anzalone, Laura Madeo, Anna Serroni, Claudia Colabella, Antonella Di Paolo, Pier Mario Mangili, Elisabetta Manuali, Andrea Felici, Monica Cagiola, Antonio Lavazza, Lorenzo Capucci, Giovanni Pezzotti, Antonio De Giuseppe   +13 more
doaj   +2 more sources

Detection of positive selection in the major capsid protein VP60 of the rabbit haemorrhagic disease virus (RHDV) [PDF]

Virus Research, 2008
Mutations were analysed in the major capsid protein VP60 of the rabbit haemorrhagic disease virus (RHDV), a calicivirus responsible for high mortality rates in both wild and domestic European rabbits (Oryctolagus cuniculus). Likelihood of positive selection was estimated using the PAML software applied to 43 non-identical complete sequences of the ...
MIGUEL Carneiro, Gertrude Thompson, Pedro Esteves   +2 more
exaly   +4 more sources

Simultaneous Occurrence of Field Epidemics of Rabbit Hemorrhagic Disease (RHD) in Poland Due to the Co-Presence of Lagovirus europaeus GI.1 (RHDV)/GI.1a (RHDVa) and GI.2 (RHDV2) Genotypes [PDF]

Viruses
The highly fatal rabbit hemorrhagic disease (RHD) that first emerged in 1984 in China has spread worldwide and affects both domestic and wild rabbits. The disease was originally caused by RHD virus (Lagovirus europaeus, L.europaeus) of GI.1 genotype, but
Andrzej Fitzner, Wiesław Niedbalski, Beata Hukowska-Szematowicz   +2 more
doaj   +2 more sources

Detection of a New Recombinant Rabbit Hemorrhagic Disease Virus 2 in China and Development of Virus-like Particle-Based Vaccine [PDF]

Viruses
Rabbit hemorrhagic disease virus (RHDV) is a very virulent virus of the genus Lagovirus causing severe and fatal hepatitis in the European rabbit (Oryctolagus cuniculus). RHDV has two distinct genotypes: GI.1 (RHDV) and GI.2 (RHDV2). The first RHDV2/GI.2
Bo Hu, Wenyu Dong, Yanhua Song, Zhiyu Fan, Patrizia Cavadini, Fang Wang   +5 more
doaj   +2 more sources

Pathological and virological insights from an outbreak of European brown hare syndrome in the Italian hare (Lepus corsicanus) [PDF]

Frontiers in Microbiology, 2023
European brown hare syndrome (EBHS) is a highly contagious and fatal viral disease, mainly affecting European brown hares (Lepus europaeus). The etiological agent, EBHS virus (EBHSV), belongs to the Lagovirus genus within the Caliciviridae family.
Mariagiovanna Domanico, Patrizia Cavadini, Roberto Nardini, Daniele Cecca, Giovanni Mastrandrea, Claudia Eleni, Valentina Galietta, Lorenzo Attili, Antonella Pizzarelli, Roberta Onorati, Cristina Amoruso, Donatella Stilli, Giulia Pacchiarotti, Francesca Merzoni, Andrea Caprioli, Ida Ricci, Antonio Battisti, Antonio Lavazza, Maria Teresa Scicluna   +18 more
doaj   +2 more sources

Two decades of occurrence of non-pathogenic rabbit lagoviruses in Italy and their genomic characterization [PDF]

Scientific Reports
Lagoviruses are viruses of the Caliciviridae family affecting lagomorphs. Both pathogenic and non-pathogenic lagoviruses affect the European rabbit (Oryctolagus cuniculus), and they are phylogenetically distinguished.
Patrizia Cavadini, Alice Vismarra, Francesca Merzoni, Vittoria Di Giovanni, Maria Beatrice Boniotti, Lorenzo Capucci, Antonio Lavazza   +6 more
doaj   +2 more sources