Results 31 to 40 of about 2,319 (158)

Molecular Design of Encapsulin Protein Nanoparticles to Display Rotavirus Antigens for Enhancing Immunogenicity

Vaccines
Rotavirus considerably threatens global health, particularly for children
Hyun-Gyo Jung, Seonghun Jeong, Min-Ji Kang, Ingi Hong, Young-Shin Park, Eunbyeol Ko, Jae-Ouk Kim, Deog-Young Choi   +7 more
doaj   +1 more source

Oral immunization of mice with Lactococcus lactis expressing the rotavirus VP8* protein [PDF]

Biotechnology Letters, 2011
The efficacy of recombinant Lactococcus lactis as a delivery vehicle for a rotavirus antigen was evaluated in a mouse model. The rotavirus VP8* protein was expressed intracellularly and extracellularly in L. lactis wild type and in an alr mutant deficient in alanine racemase activity, necessary for the synthesis of the cell-wall component D: -alanine ...
Rodríguez Díaz, Jesús, Montava, Rebeca, Viana, R., Buesa, Javier, Pérez Martínez, Gaspar, Monedero, V.   +5 more
openaire   +3 more sources

Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics

Journal of Virus Eradication
The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create
Hassan Yarmohammadi, Abbas Akhavan Sepahi, Mojtaba Hamidi-fard, Mohammadreza Aghasadeghi, Golnaz Bahramali   +4 more
doaj   +1 more source

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca ²⁺

, 2023
ABSTRACT Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from which the DLPs escape.
Marilina De Sautu, Tobias Herrmann, Simon Jenni, Stephen C. Harrison   +3 more
openaire   +2 more sources

Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach.

PLoS ONE, 2023
BackgroundRotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and middle-income ...
Katayi Mwila-Kazimbaya, Samuel Bosomprah, Obvious Nchimunya Chilyabanyama, Caroline Cleopatra Chisenga, Mwelwa Chibuye, Natasha Makabilo Laban, Michelo Simuyandi, Bert Huffer, Miren Iturriza-Gomara, Robert K M Choy, Roma Chilengi   +10 more
doaj   +1 more source

Specificity and Affinity of Sialic Acid Binding by the Rhesus Rotavirus VP8* Core [PDF]

Journal of Virology, 2002
ABSTRACT Nuclear magnetic resonance spectroscopy demonstrates that the rhesus rotavirus hemagglutinin specifically binds α-anomeric N -acetylneuraminic acid with a K d of 1.2 mM. The hemagglutinin requires no additional carbohydrate moieties
Dormitzer, Philip R., Sun, Zhen-Yu J., Blixt, Ola, Paulson, James C., Wagner, Gerhard, Harrison, Stephen C.   +5 more
openaire   +4 more sources

Mechanism underlying the DNA-binding preferences of the Vibrio cholerae and vibriophage VP882 VqmA quorum-sensing receptors.

PLoS Genetics, 2021
Quorum sensing is a chemical communication process that bacteria use to coordinate group behaviors. In the global pathogen Vibrio cholerae, one quorum-sensing receptor and transcription factor, called VqmA (VqmAVc), activates expression of the vqmR gene ...
Olivia P Duddy, Xiuliang Huang, Justin E Silpe, Bonnie L Bassler   +3 more
doaj   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Vaccinia virions lacking core protein VP8 are deficient in early transcription [PDF]

Journal of Virology, 1996
When synthesis of the 25-kDa vaccinia virus core protein VP8 is repressed, mature virus particles of normal appearance are produced to approximately 80% of wild-type levels but these particles are over 100-fold less infectious than wild-type particles (D. Wilcock and G. L. Smith, Virology 202:294-304, 1994). Here we show that virions which lack VP8 can
D, Wilcock, G L, Smith
openaire   +2 more sources

A Pseudovirus Nanoparticle-Based Trivalent Rotavirus Vaccine Candidate Elicits High and Cross P Type Immune Response

Pharmaceutics, 2022
Rotavirus infection continues to cause significant morbidity and mortality globally. In this study, we further developed the S60-VP8* pseudovirus nanoparticles (PVNPs) displaying the glycan receptor binding VP8* domains of rotavirus spike proteins as a ...
Ming Xia, Pengwei Huang, Ming Tan
doaj   +1 more source