Results 31 to 40 of about 3,267 (159)

Interaction of VP8 with mRNAs of bovine herpesvirus-1

Virus Research, 2015
The UL47 gene product, VP8, is one of the most abundant tegument proteins of bovine herpesvirus-1 (BoHV-1). Deletion of VP8 leads to impaired growth in tissue culture, and VP8 is indispensable for BHV-1 replication in cattle. To elucidate the biological functions of VP8, we explored its interaction with mRNAs of immediate early (bICP0), early (gB, gD ...
Azharul, Islam, Sandra, Schulz, Sharmin, Afroz, Lorne A, Babiuk, Sylvia, van Drunen Littel-van den Hurk   +4 more
openaire   +2 more sources

Oral immunization of mice with Lactococcus lactis expressing the rotavirus VP8* protein [PDF]

Biotechnology Letters, 2011
The efficacy of recombinant Lactococcus lactis as a delivery vehicle for a rotavirus antigen was evaluated in a mouse model. The rotavirus VP8* protein was expressed intracellularly and extracellularly in L. lactis wild type and in an alr mutant deficient in alanine racemase activity, necessary for the synthesis of the cell-wall component D: -alanine ...
Rodríguez Díaz, Jesús, Montava, Rebeca, Viana, R., Buesa, Javier, Pérez Martínez, Gaspar, Monedero, V.   +5 more
openaire   +3 more sources

Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens.

PLoS Pathogens, 2020
Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4.
Shenyuan Xu, Luay U Ahmed, Michael Robert Stuckert, Kristen Rose McGinnis, Yang Liu, Ming Tan, Pengwei Huang, Weiming Zhong, Dandan Zhao, Xi Jiang, Michael A Kennedy   +10 more
doaj   +1 more source

Effects of Rotavirus NSP4 on the Immune Response and Protection of Rotavirus-Norovirus Recombinant Subunit Vaccines in Different Immune Pathways

Vaccines
Diarrheal disease continues to be a major cause of global morbidity and mortality among children under 5 years of age. To address the current issues associated with oral attenuated rotavirus vaccines, the study of parenteral rotavirus vaccines has ...
Jingping Hu, Jinyuan Wu, Han Cao, Ning Luan, Kangyang Lin, Haihao Zhang, Dandan Gao, Zhentao Lei, Hongjun Li, Cunbao Liu   +9 more
doaj   +1 more source

Structural Correlates of Rotavirus Cell Entry [PDF]

, 2014
Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA viruses, a complete subviral particle.
Abdelhakim, Aliaa H., Fu, Xiaofeng, Harrison, Stephen C., Kirchhausen, Tomas, Nicastro, Daniela, Pasham, Mithun, Salgado, Eric N.   +6 more
core   +4 more sources

Molecular Design of Encapsulin Protein Nanoparticles to Display Rotavirus Antigens for Enhancing Immunogenicity

Vaccines
Rotavirus considerably threatens global health, particularly for children
Hyun-Gyo Jung, Seonghun Jeong, Min-Ji Kang, Ingi Hong, Young-Shin Park, Eunbyeol Ko, Jae-Ouk Kim, Deog-Young Choi   +7 more
doaj   +1 more source

Large deviations for polling systems [PDF]

, 2000
Related INRIA Research report available at : http://hal.inria.fr/docs/00/07/27/62/PDF/RR-3892.pdfInternational audienceWe aim at presenting in short the technical report, which states a sample path large deviation principle for a resealed process n-1 Qnt,
A Fortelle De La, AA Borovkov, C Fricker, D Down, F Delcoigne, H Takagi, I Ignatiouk-Robert, I Nagot, IA Ignatyuk, O Boxma, P Dupuis, P Dupuis, P Dupuis, P Dupuis, R Atar, RL Dobrushin, RL Dobrushin   +16 more
core   +4 more sources

Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [PDF]

Vaccine, 2012
Two currently licensed live oral rotavirus vaccines (Rotarix® and RotaTeq®) are highly efficacious against severe rotavirus diarrhea. However, the efficacy of such vaccines in selected low-income African and Asian countries is much lower than that in middle or high-income countries.
Xiaobo, Wen, Dianjun, Cao, Ronald W, Jones, Jianping, Li, Shousun, Szu, Yasutaka, Hoshino   +5 more
openaire   +2 more sources

Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics

Journal of Virus Eradication
The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create
Hassan Yarmohammadi, Abbas Akhavan Sepahi, Mojtaba Hamidi-fard, Mohammadreza Aghasadeghi, Golnaz Bahramali   +4 more
doaj   +1 more source

Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach.

PLoS ONE, 2023
BackgroundRotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and middle-income ...
Katayi Mwila-Kazimbaya, Samuel Bosomprah, Obvious Nchimunya Chilyabanyama, Caroline Cleopatra Chisenga, Mwelwa Chibuye, Natasha Makabilo Laban, Michelo Simuyandi, Bert Huffer, Miren Iturriza-Gomara, Robert K M Choy, Roma Chilengi   +10 more
doaj   +1 more source