Results 21 to 30 of about 2,319 (158)
Formulation and preclinical studies with a trivalent rotavirus P2-VP8 subunit vaccine [PDF]
Human Vaccines & Immunotherapeutics, 2020 More effective rotavirus vaccines are essential for preventing extensive diarrheal morbidity and mortality in children under five years of age in low-resource regions. Nonreplicating rotavirus vaccines (NRRV) administered parenterally provide an alternate vaccination method to the current licensed oral vaccine. Live attenuated vaccines and may generate
Kyle Lakatos +3 more
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Pathogens, 2022 Sicily was the first Italian region to introduce rotavirus (RV) vaccination with the monovalent G1P[8] vaccine Rotarix® in May 2012. In this study, the seasonal distribution and molecular characterization of RV strains detected over 19 years were ...
Floriana Bonura +7 more
doaj +1 more source
The Vaccinia virion: Filling the gap between atomic and ultrastructure.
PLoS Pathogens, 2019 We have investigated the molecular-level structure of the Vaccinia virion in situ by protein-protein chemical crosslinking, identifying 4609 unique-mass crosslink ions at an effective FDR of 0.33%, covering 2534 unique pairs of crosslinked protein ...
Yeva Mirzakhanyan, Paul Gershon
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PLoS Pathogens, 2023 The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome ...
Wenfang S Tan +7 more
doaj +1 more source
Distribution of conserved and specific epitopes on the VP8 subunit of rotavirus VP4 [PDF]
Journal of Virology, 1992 Three cDNA clones comprising the VP8 subunit of the VP4 of human rotavirus strain KU (VP7 serotype G1; VP4 serotype P1A) G1 were constructed. The corresponding encoded peptides were designated according to their locations in the VP8 subunit as A (amino acids 1 to 102), B (amino acids 84 to 180), and C (amino acids 150 to 246 plus amino acids 247 to 251
G, Larralde, M, Gorziglia
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Protein & Cell, 2016 Virus infection consists of entry, synthesis of macromolecular components, virus assembly and release. Understanding of the mechanisms underlying each event is necessary for the intervention of virus infection in human healthcare and agriculture. Here we
Yongming Yuan, Yunhan Hong
doaj +1 more source
Transmission of potato spindle tuber viroid between Phytophthora infestans and host plants
Вавиловский журнал генетики и селекции, 2022 Potato spindle tuber viroid (PSTVd) is a naked, circular, single-stranded RNA (356–363 nucleotides in length) which lacks any protein-coding sequences.
O. S. Afanasenko +3 more
doaj +1 more source
PLoS Pathogens, 2020 Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4.
Shenyuan Xu +10 more
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Glycan binding patterns of human rotavirus P[10] VP8* protein [PDF]
Virology Journal, 2018 Los rotavirus (RV) son una causa importante de gastroenteritis aguda infantil. El rotavirus P [10] pertenece al genogrupo P[I] de los rotavirus del grupo A que infectan principalmente a los animales, mientras que el rotavirus P [10] se identificó principalmente a partir de la infección humana.
Lili Pang +8 more
openaire +3 more sources
VaccinesDiarrheal disease continues to be a major cause of global morbidity and mortality among children under 5 years of age. To address the current issues associated with oral attenuated rotavirus vaccines, the study of parenteral rotavirus vaccines has ...
Jingping Hu +9 more
doaj +1 more source