Results 121 to 130 of about 20,255 (238)

Viral replication is enhanced by an HIV-1 intersubtype recombination-derived Vpu protein

Virology Journal, 2010
Background Multiple HIV-1 intersubtype recombinants have been identified in human populations. Previous studies from our lab group have shown that the epidemic in Argentina is characterized by the high prevalence of a circulating recombinant form ...
Salomón Horacio, Turk Gabriela, Ghiglione Yanina, Duette Gabriel, Espada Constanza, De Candia Cristian, Carobene Mauricio   +6 more
doaj   +1 more source

K2P channels and their protein partners. [PDF]

, 2005
A decade since their discovery, the K2P channels are recognized as pathways dedicated to regulated background leakage of potassium ions that serve to control neuronal excitability. The recent identification of protein partners that directly interact with
Goldstein, Steve AN, Plant, Leigh D, Rajan, Sindhu   +2 more
core   +1 more source

Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. [PDF]

, 2005
In order to study the inhibitory effect of various reverse transcriptase inhibitors (RTIs) on cell-free HIV, we adapted a recently described in vitro system, based on co-cultures of dendritic cells and resting CD4 T cells, modelling early target cells ...
Andries, Koen, Fransen, K., Garcia, S., Janssen, C.G.M., Janssen, P.A.J., Kestens, Luc, Lewi, Paul, Njai, H.F., Vanham, Guido   +8 more
core  

Lack of adaptation to human tetherin in HIV-1 Group O and P

Retrovirology, 2011
Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite the same genomic organization, only the group M viruses are responsible for the world-wide pandemic of AIDS, suggesting better adaptation to human hosts ...
Haworth Kevin G, Exline Colin M, Lopez Lisa A, Yang Su Jung, Cannon Paula M   +4 more
doaj   +1 more source

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

PLoS Pathogens, 2010
The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface.
Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen   +6 more
doaj   +1 more source

The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells.

PLoS ONE, 2014
There is faster progression to fibrosis in persons with liver injury who are also infected with HIV. Other reports have suggested that HIV can directly infect and activate stellate cells, and the viral Tat and gp160 proteins also induce profibrogenic ...
Paresh Patel, Nabab Khan, Manjusha Rani, Deepti Gupta, Shahid Jameel   +4 more
doaj   +1 more source

Z-graded weak modules and regularity

, 2011
It is proved that if any Z-graded weak module for vertex operator algebra V is completely reducible, then V is rational and C_2-cofinite. That is, V is regular.
C. Dong, C. Dong, C. Dong, C. Dong, C. Dong, C. Dong, Chongying Dong, H. Li, I. Frenkel, I. Frenkel, I. Frenkel, M. Karel, M. Miyamoto, Nina Yu, R. Borcherds, T. Abe, T. Abe, T. Abe, W. Wang, Y. Huang, Y. Zhu   +20 more
core   +1 more source

Validating Vegetable Production Unit (VPU) Plants, Protocols, Procedures and Requirements (P3R) using Currently Existing Flight Resources [PDF]

Validating Vegetable Production Unit (VPU) Plants, Protocols, Procedures and Requirements (P3R) Using Currently Existing Flight Resources (Lada-VPU-P3R) is a study to advance the technology required for plant growth in microgravity and to research ...
Bates, Scott, Bingham, Gail, Bugbee, Bruce, Garland, Jay, Gushin, Vadim, Levinskikh, Rita, Podolski, Igor, Sychev, Vladimir   +7 more
core   +1 more source

In-vivo mutation rates and fitness landscape of HIV-1

, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan, Brodin, Johanna, Neher, Richard, Puller, Vadim, Zanini, Fabio   +4 more
core   +1 more source

Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.

Cell Reports, 2018
Accessory proteins of lentiviruses, such as HIV-1, target cellular restriction factors to enhance viral replication. Systematic analyses of proteins that are targeted for degradation by HIV-1 accessory proteins may provide a better understanding of viral 
P. Jain, Guney Boso, Simon Langer, Stephen Soonthornvacharin, Paul D. De Jesus, Q. Nguyen, Kevin C. Olivieri, A. Portillo, S. Yoh, L. Pache, S. Chanda   +10 more
semanticscholar   +1 more source