Results 111 to 120 of about 20,255 (238)

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses

mBio, 2019
The restriction factor BST-2 and the NK cell ligands NTB-A and PVR are among a growing list of membrane proteins found to be downregulated by HIV-1 Vpu.
Jérémie Prévost, S. Pickering, Mitchell J Mumby, H. Medjahed, Gabrielle Gendron-Lepage, G. Delgado, Brennan S. Dirk, J. Dikeakos, C. Stürzel, D. Sauter, F. Kirchhoff, F. Bibollet-Ruche, B. Hahn, M. Dubé, D. Kaufmann, S. Neil, A. Finzi, J. Richard   +17 more
semanticscholar   +1 more source

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration, Volume 5, Issue 1, February 2025.
Within this review, an in‐depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune‐mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs ...
Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun   +10 more
wiley   +1 more source

The design of retroviral vectors used in the CAR‐T products, risk management, and future perspective

MedComm, Volume 6, Issue 2, February 2025.
This article compares gamma retroviral and lentiviral vectors, discussing packaging systems and SIN vector design. It also covers risks of secondary malignancies linked to retroviral vectors and strategies to minimize them. The article explores the regulatory framework, safety monitoring, and future safety improvements for CAR‐T therapy, emphasizing a ...
Huifang Yin, Xuejing Wei
wiley   +1 more source

βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin

Viruses, 2018
The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein
Yul Eum Song, Daniel Cyburt, Tiffany M. Lucas, Devon A. Gregory, Terri D. Lyddon, Marc C. Johnson   +5 more
doaj   +1 more source

SKP1‐CUL1‐F‐box: Key molecular targets affecting disease progression

The FASEB Journal, Volume 39, Issue 2, 31 January 2025.
SCF complexes are widely involved in intracellular metabolism. In this paper, we discuss the diverse effects of SCF on crucial cellular processes such as cell cycle progression, cell migration, biological rhythms, DNA replication, cell differentiation, cell, apoptosis, immune response, and disease occurrence.
Xiangrong Zeng, Jiaying Cao, Juan Xu, Zihua Zhou, Chen Long, Yanhong Zhou, Jingqiong Tang   +6 more
wiley   +1 more source

Genetic and Functional Characterization of HIV-1 Vpu from HIV-1-Infected North Indian Population

BioResearch Open Access, 2020
Acquired immunodeficiency syndrome is a pandemic disease due to increased variability in causative agent in global distribution; it is attributed to various complications in developing the vaccine, namely, error-prone reverse transcriptase, rapid ...
Jyotsna Singh, M. Pandey, V. Ramachandran, A. Banerjea   +3 more
semanticscholar   +1 more source

Effect of Ocimum basiicum L. essential oil microemulsion on the quality of snakehead (Channa argus) under different dipping conditions during cold storage

JSFA reports, Volume 5, Issue 1, Page 14-26, January 2025.
Abstract Background Ocimum basiicum L. essential oil (OBEO) is an herbal essential oil that inhibits microbial activity during food preservation. However, preservation of aquatic products is susceptible to environmental factors. The efficacy of different impregnation techniques was evaluated.
Yanhan Li, Yao Xie, Jun Mei, Jing Xie
wiley   +1 more source

Synchronisation, Optimisation and Adaptation of Machine Learning Techniques for Computer Vision in Cyber‐Physical Systems: A Comprehensive Analysis

IET Cyber-Physical Systems: Theory &Applications, Volume 10, Issue 1, January/December 2025.
This systematic analysis aims to offer a unique point to researchers and facilitates this process by allowing researchers to benchmark and compare various techniques, evaluate their effectiveness and establish best practices. It provides evidence‐based insights into optimal strategies for implementation while addressing potential trade‐offs in ...
Kai Hung Tang, Mohamed Chahine Ghanem, Pawel Gasiorowski, Vassil Vassilev, Karim Ouazzane   +4 more
wiley   +1 more source

Survey of VPU olympiad for young mathematicians

Lietuvos matematikos rinkinys, 2009
The article presents problems of VPU Young Mathematicians‘ Olympiad 2009, their solution and a short statistical anglysis of Lithuanian Olympiad movemenr of mathematicians.
Eglė Jakaitytė, Edmundas Mazėtis
openaire   +3 more sources