Results 31 to 40 of about 10,974 (221)

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

mSphere, 2022
Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls mediated via the
Gustavo Bravo Ruiz, Michele Tinti, Melanie Ridgway, David Horn   +3 more
doaj   +1 more source

Antigenic variation in African trypanosomes [PDF]

, 2014
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T.
Horn, David; id_orcid
core   +1 more source

Purified soluble VSG identification.

, 2021
(A) Coomassie stained SDS-PAGE of purified soluble VSG solution denoting a single preeminent band within the predicted size range of VSG. (B) Best peptide match within the SwissProt database (sp|P06015|VSA1_TRYBB, Variant surface glycoprotein AnTaT 1.1 ...
Karine Serre (218619), Luisa M. Figueiredo (7841315), Tiago Bizarra-Rebelo (11436975), Sandra Trindade (211750), Henrique Machado (5644883), Mariana Costa-Sequeira (11436978), Filipa Rijo-Ferreira (3334551), Barbara Rentroia-Pacheco (11436981), Tânia Carvalho (109163)   +8 more
core   +1 more source

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]

, 2013
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Lucy Glover (24966), Sam Alsford, David Horn (24969), Alsford, Sam, Lucy Glover, Sam Alsford (24967), David Horn, Glover Lucy, Alsford Sam, Horn David   +12 more
core   +1 more source

Transition Towards Inverter-based Generation with VSG Control: Low Frequency Instability Prospective [PDF]

, 2023
The proliferation of inverter-based resources (IBRs) with conventional control methods can result in significant power oscillations following disturbances. This is due to insufficient inertia and lack of damping with IBRs.
Feng, J, Nadarajah, M, Ma, H, Bai, F
core   +1 more source

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

eLife, 2023
African trypanosomes evade host immune clearance by antigenic variation, causing persistent infections in humans and animals. These parasites express a homogeneous surface coat of variant surface glycoproteins (VSGs).
Abdoulie O Touray, Rishi Rajesh, Tony Isebe, Tamara Sternlieb, Mira Loock, Oksana Kutova, Igor Cestari   +6 more
doaj   +1 more source

Developmental progression of VSG expression.

, 2021
A. VSG expression data for a random subset of 50 pre-metacyclic cells, with a total VSG UMI count > 10. Data are raw (unscaled) UMI counts. Each column represents a cell and each colour a different VSG. B.
Sebastian Hutchinson (3500945), Sophie Foulon (11457994), Philippe Bastin (25974), Roberta Menafra (577964), Brice Rotureau (336607), Andrew D. Griffiths (1898392), Aline Crouzols (5309936)   +6 more
core   +1 more source

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]

, 2005
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C, McCulloch, Richard, Proudfoot, Christopher, McCulloch, R   +3 more
core   +1 more source

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing

mSphere, 2022
African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG).
Mohamed Sharif, Paige Garrison, Peter Bush, James D. Bangs   +3 more
doaj   +1 more source

Current-Limiting VSG for Renewable Energy Applications

2021 IEEE 30th International Symposium on Industrial Electronics (ISIE), 2021
In this paper, an improved nonlinear controller structure, which inherits both virtual inertia (VI) and current-limiting properties in grid-connected voltage-source converters (VSCs), is proposed. The proposed method inherits the V dc ~ ω droop control for inertia emulation and frequency control, and Q ~ V droop control for AC voltage support.
Dedeoglu, S., Konstantopoulos, G.C., Komurcugil, H.   +2 more
openaire   +2 more sources