Mapping of VSG similarities in Trypanosoma brucei [PDF]
The protozoan parasite Trypanosoma brucei switches its variant surface glycoprotein (VSG) to subvert its mammalian hosts' immune responses. The T. brucei genome contains as many as 1600 VSG genes (VSGs), but most are silent noncoding pseudogenes. Only one functional VSG, located in a telomere-linked expression site, is transcribed at a time.
Jason L, Weirather +2 more
openaire +2 more sources
Inertia Lifting of New Energy Power System Based on VSG Droop Optimal Control [PDF]
Aiming at the problems of poor dynamic performance of traditional VSG technology and difficulty to determine the optimal values of important parameters J and D, a VSG control and parameter optimization strategy based on droop control and neural network ...
WANG Mingdong +3 more
doaj +1 more source
A histone methyltransferase modulates antigenic variation in African trypanosomes [PDF]
To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Janzen, Christian J. +8 more
core +1 more source
Genome hyperevolution and the success of a parasite [PDF]
The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals.
J. David Barry +5 more
core +1 more source
Suppression of synchronous resonance for VSGs [PDF]
The virtual synchronous generator (VSG) is an attractive interfacing technique for high‐penetration renewable generation. By incorporating the inertia control, the grid‐connected voltage‐source converter can behave in a similar way with the SGs, which is helpful to enhance the stability of the power system.
Dongsheng Yang +3 more
openaire +2 more sources
Blocking Variant Surface Glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation [PDF]
Background: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Gluenz Eva +33 more
core +2 more sources
Filtering of the minichromosomal VSG set.
The VSG set was filtered based on RNA-seq read-mapping profiles. VSGs displaying full coding sequence activation were included in the analysis. VSGs with mapped reads restricted to the C-terminal coding sequence were excluded from further analysis. These
Michele Tinti (75217) +4 more
core +1 more source
Functional insights from a surface antigen mRNA-bound proteome
Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG
Larissa Melo do Nascimento +5 more
doaj +1 more source
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H. +57 more
core +1 more source
Modification of Control System Based on Virtual Synchronous Generator with Feedforward Control for Power Converters of Distributed Generation [PDF]
An important development trend for modern power systems is the application of control algorithms for power converters based on a virtual synchronous generator (VSG), which can mimic the characteristics of the conventional synchronous generation and ...
Askarov Alisher +3 more
doaj +1 more source

