Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls mediated via the
Gustavo Bravo Ruiz +3 more
doaj +1 more source
Inertia Lifting of New Energy Power System Based on VSG Droop Optimal Control [PDF]
Aiming at the problems of poor dynamic performance of traditional VSG technology and difficulty to determine the optimal values of important parameters J and D, a VSG control and parameter optimization strategy based on droop control and neural network ...
WANG Mingdong +3 more
doaj +1 more source
Antigenic variation in Trypanosoma brucei: joining the DOTs [PDF]
African trypanosomes, such as <i>Trypanosoma brucei</i>, are protistan parasites that cause sleeping sickness. Though first described more than a century ago, trypanosomes remain a blight on the health of the human population and on the ...
Swiderski, Michal R. +11 more
core +1 more source
Suppression of synchronous resonance for VSGs [PDF]
The virtual synchronous generator (VSG) is an attractive interfacing technique for high‐penetration renewable generation. By incorporating the inertia control, the grid‐connected voltage‐source converter can behave in a similar way with the SGs, which is helpful to enhance the stability of the power system.
Dongsheng Yang +3 more
openaire +2 more sources
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H. +58 more
core +1 more source
Antigenic variation in African trypanosomes [PDF]
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T.
Horn, David; id_orcid
core +1 more source
Genome hyperevolution and the success of a parasite [PDF]
The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals.
J. David Barry +5 more
core +1 more source
Modification of Control System Based on Virtual Synchronous Generator with Feedforward Control for Power Converters of Distributed Generation [PDF]
An important development trend for modern power systems is the application of control algorithms for power converters based on a virtual synchronous generator (VSG), which can mimic the characteristics of the conventional synchronous generation and ...
Askarov Alisher +3 more
doaj +1 more source
Functional insights from a surface antigen mRNA-bound proteome
Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG
Larissa Melo do Nascimento +5 more
doaj +1 more source
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy +9 more
core +1 more source

