Results 11 to 20 of about 8,926 (229)
Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes [PDF]
Frontiers in Cell and Developmental Biology, 2022 The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
doaj +2 more sources
Cohesin regulates VSG monoallelic expression in trypanosomes [PDF]
Journal of Cell Biology, 2009 Antigenic variation allows Trypanosoma brucei to evade the host immune response by switching the expression of 1 out of ∼15 telomeric variant surface glycoprotein (VSG) expression sites (ESs). VSG ES transcription is mediated by RNA polymerase I in a discrete nuclear site named the ES body (ESB).
Landeira, David +3 more
openaire +4 more sources
Pathogens, 2021 Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response.
Bibo Li, Yanxiang Zhao
doaj +1 more source
SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2014 Bloodstream form trypanosomes avoid the host immune response by switching the expression of their surface proteins between Variant Surface Glycoproteins (VSG), only one of which is expressed at any given time.
Diana López-Farfán +3 more
doaj +1 more source
Energies, 2023 Virtual synchronous generators (VSG) are considered a new generation of grid-friendly inverters with the same inertial support characteristics as synchronous generators (SG). However, the inertia support comes with the side effects of power and frequency
Hao Liu +4 more
doaj +1 more source
基于模型预测控制的光储发电系统VSG频率控制方法 [PDF]
, 2022 随着光伏发电装机规模大幅提升，电力系统转动惯量不断降低，虚拟同步发电机（virtual synchronous generator，VSG）技术被广泛采用以应对日益严峻的电网稳定性问题。为进一步提高VSG技术对系统稳定性的改善作用，提出基于模型预测控制的VSG频率控制方法。该方法首先在同步发电机转子运动方程和逆变器下垂控制方程基础上建立VSG可优化的离散模型，再通过模型预测控制（model predictive control，MPC）预测VSG转子角频率的运动轨迹 ...
张志丹 +3 more
core +1 more source
mBio, 2022 In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin +3 more
doaj +1 more source
Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]
, 1990 The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Matthews, K R; id_orcid +3 more
core +1 more source
Mapping of VSG similarities in Trypanosoma brucei [PDF]
Molecular and Biochemical Parasitology, 2012 The protozoan parasite Trypanosoma brucei switches its variant surface glycoprotein (VSG) to subvert its mammalian hosts' immune responses. The T. brucei genome contains as many as 1600 VSG genes (VSGs), but most are silent noncoding pseudogenes. Only one functional VSG, located in a telomere-linked expression site, is transcribed at a time.
Jason L, Weirather +2 more
openaire +2 more sources
A histone methyltransferase modulates antigenic variation in African trypanosomes [PDF]
, 2008 To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Janzen, Christian J. +8 more
core +1 more source