Results 131 to 140 of about 56,101 (281)
HETEROGENEITY OF ANTI-VON WILLEBRAND FACTOR (VWF) ANTIBODIES WHICH INHIBIT RISTOCETIN-INDUCED VWF BINDING TO PLATELET GLYCOPROTEIN (GP)Ⅰb [PDF]
, 1989 The epitopes of four anti-vWF monoclonal antibodies (MoAbs), which inhibit antibiotic ristocetin induced vWF binding to GPⅠb, were investigated and compared with each other.
高瀬, 俊夫 +8 more
core
Effect of vWF on Notch signaling.
, 2013 A co-culture system was used to assess the effects of vWF on Notch signaling in H460 (A) and A7R5 (B) cells reflected by ligand stimulation of HES-luciferase. Experiments were performed in either serum-containing or serum-free media supplemented with vWF
He Meng (33363) +3 more
core +1 more source
Diabetic Medicine, EarlyView.Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo +4 more
wiley +1 more source
PLoS ONEAlterations in von Willebrand factor (VWF) have an important role in human health and disease. Deficiency of VWF is associated with symptoms of bleeding and excesses of VWF are associated with thrombotic outcomes.
Allaura A Cox +2 more
doaj +1 more source
Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins +7 more
wiley +1 more source
Recent advances in the diagnosis of von Willebrand disease
LabMed DiscoveryVon Willebrand disease (VWD) is caused by a quantitative or qualitative defect of von Willebrand factor (VWF). Despite its prevalence as the most common hereditary bleeding disorder and the associated morbidity, its diagnosis and classification remains a
Qian Liang, Renhao Li
doaj +1 more source
Identification of a VWF gene mutation.
, 2013 Sequence analysis of the VWF gene in the proband detected a 6-bp nucleotides deletion in exon 28. The mutation caused D1529V1530 deletion (ΔD1529V1530) in VWF A2 domain. The ADAMTS13 cleavage site is indicated by an arrow.
Ningzheng Dong (328283) +7 more
core +1 more source
Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source
VWF cleavage by endothelial cell lysates depicted by immunoblotting.
, 2013 A. Recombinant ADAMTS13 cleaves the A2 domain of VWF whereby 176 kDa and 140 kDa bands appear (lane 1). Full-length VWF is depicted by an arrow. Cell buffer, incubated with VWF and used as the negative control, did not exhibit the cleavage fragments ...
David Motto (349293) +8 more
core +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman +10 more
wiley +1 more source