Results 161 to 170 of about 69,458 (313)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The role of platelet membrane proteins in the interaction of platelet-vWF-collagen.

, 1988
Morio Aihara, Yoshihiro Tamura, IKUO KUDO, Yoshihiko Sawada, Masaki Munakata, N Moriya, Shigeo Morimoto, Yutaka Yoshida   +7 more
openalex   +2 more sources

C1qTNF–related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen [PDF]

, 2005
Gerald Lasser, Prasenjit Guchhait, Jeff L. Ellsworth, Paul O. Sheppard, Ken Lewis, Paul D. Bishop, Miguel A. Crúz, José A. López, Joachim Fruebis   +8 more
openalex   +1 more source

Heterogeneity in Osteosarcoma Revealed by scRNA Sequencing: CLU+ Endothelial Cells as Key Players in Tumor Progression

Cancer Science, EarlyView.
This study investigates the intratumoral heterogeneity (ITH) in osteosarcoma by analyzing paired tumor tissue samples from the central and peripheral regions of six patients using single‐cell RNA sequencing. The findings reveal significant microenvironmental differences, with the central region enriched in immune cells and the peripheral region ...
Zhehao Dai, Peng Xie, Xiangzhi Bai, Tang Liu, Xiaoning Guo, Lei Kuang, Ping Mu, Fangjin Lu   +7 more
wiley   +1 more source

Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an αIIbβ3- and aggregation-independent manner [PDF]

, 2005
Junling Liu, Tamara I. Pestina, Michael C. Berndt, Carl W. Jackson, T. Kent Gartner   +4 more
openalex   +1 more source

FKBP5 Mediates Alveolar Fibroblast Necroptosis During Acute Respiratory Distress Syndrome

Cell Proliferation, EarlyView.
Structure diagram of alveolar fibroblast activation in septic ARDS model. FKBP5‐mediated alveolar fibroblast necroptosis, leading to the activation of NF‐κB signalling and the secretion of cytokines and the recruitment of neutrophils, and further orchestrating the inflammatory environment of the alveolar epithelia in septic ARDS.
Dong Zhang, Wei Liu, Ting Sun, Yangyang Xiao, Qiuwen Chen, Xiao Huang, Xiaozhi Wang, Qian Qi, Hao Wang, Tao Wang   +9 more
wiley   +1 more source

Challenges and considerations of genetic testing in von Willebrand disease

Research and Practice in Thrombosis and Haemostasis
von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by defects in the quantity or function of the von Willebrand factor (VWF).
Omid Seidizadeh, Luciano Baronciani, Flora Peyvandi   +2 more
doaj  

Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4, which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein Ib

, 1991
Yoshihiro Fujimura, Yoshiko Usami, Koiti Titani, K. Niinomi, Kenji Nishio, T Takase, Akira Yoshioka, Hiromu Fukui   +7 more
openalex   +1 more source

Fatal relapse of thrombotic thrombocytopaenic purpura after cardiac surgery in patient with congenital absence of vWF-cleaving protease activity [PDF]

, 2006
Nikolina Bašić‐Jukić, Petar Kes, Bruna Brunetta   +2 more
openalex   +1 more source

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source