Results 41 to 50 of about 60,545 (283)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Clinical phenotype and pathophysiological mechanisms underlying qualitative Low VWF [PDF]

Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduction in plasma VWF activity levels in the 30 to 50 IU/dL range. These patients had
Doyle, Mairead, van Galen, Karin P M, Schols, Saskia E M, Preston, Roger J S, van Kwawegen, Calvin B., Cnossen, Marjon H., Heubel-Moenen, Floor C J I, Baker, Ross I., van der Bom, Johanna G, Eikenboom, Jeroen C J, Leebeek, Frank W G, Heubel-Moenen, Floor C.J.I., van Heerde, Waander L, James, Paula, Doyle, Mairead M, Di Paola, Jorge, van Kwawegen, Calvin, O'Donnell, James S, Schols, Saskia E.M., O'Connell, Niamh M, Cnossen, Marjon H, James, Paula D, van der Bom, Johanna G., Meijer, Karina; id_orcid, Fijnvandraat, Karin, Atiq, Ferdows, Preston, Roger J.S., O'Donnell, James S., Doherty, Dearbhla, Baker, Ross Ian, Blok, Robin, de Meris, Joke, Hulshof, Anne-Marije, Byrne, Mary B, Hulshof, Anne Marije, Leebeek, Frank W.G.; id_orcid, Meijer, Karina, O'Connell, Niamh M., van Galen, Karin P.M., Leebeek, Frank W.G., Byrne, Mary, Lavin, Michelle, Eikenboom, Jeroen, Ryan, Kevin, van Heerde, Waander L.   +44 more
core   +5 more sources

Identification and functional analysis of a novel von Willebrand factor mutation in a family with type 2A von Willebrand disease. [PDF]

PLoS ONE, 2012
von Willebrand factor (VWF) is essential for normal hemostasis. VWF gene mutations cause the hemorrhagic von Willebrand disease (VWD). In this study, a 9-year-old boy was diagnosed as type 2A VWD, based on a history of abnormal bleeding, low plasma VWF ...
Jing Dong, Xiaojuan Zhao, Sensen Shi, Zhenni Ma, Meng Liu, Qingyu Wu, Changgeng Ruan, Ningzheng Dong   +7 more
doaj   +1 more source

Angiogenesis and the ADAMTS13-VWF balance [PDF]

Blood, 2017
In this issue of Blood , Xu et al describe a new function for the metalloprotease ADAMTS13 in blood vessel formation following brain ischemia. Using multiple approaches in mice, they show that ADAMTS13 is required for neovascularization and vascular repair following ischemic stroke.
openaire   +2 more sources

vWF immunostaining.

, 2022
hVICs and hVECs stained for vWF (green), phalloidin (red), and DAPI (blue). Scale bars represent 100μm.
Karen Callon (3219756), Robert Walker (78026), Paget Milsom (12889989), Jillian Cornish (3219759), Marcus Ground (12889983), Steve Waqanivavalagi (12889986), Young-Eun Park (11607026)   +6 more
core   +1 more source

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis

Clinical and Applied Thrombosis/Hemostasis, 2020
von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD).
Bin Yan MS, Qi Wang MS, Weipeng Du BS, Suping Zhai BS, Chaoyang Gou MS, Tianxi Hu BS, Lijun Xia PhD, Changgeng Ruan PhD, Yiming Zhao PhD   +8 more
doaj   +1 more source

Calculated VWF excess and VWF half-life in pregnancy.

, 2014
Calculated VWF excess and VWF half-life in pregnancy.
Gayle T. Teramura (698015), Dominic W. Chung (126493), Hilary S. Gammill (345254), Barbara A. Konkle (698017), Kerry W. Lannert (698014), Jill M. Johnsen (698018), Danielle N. Drury-Stewart (698013), James C. Zimring (698016)   +7 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

On the issue of recurrent thrombosis in cancer patients

Акушерство, гинекология и репродукция
Aim: to identify the key pathogenic factors and triggers associated with recurrent venous thromboembolic events (VTE) in gynaecological oncology patients.Materials and Methods.
K. N. Grigoreva, V. O. Bitsadze, A. V. Vorobev, A. G. Solopova, J. Kh. Khizroeva, A. Z. Iakubov, J. Yu. Ungiadze, I. S. Kalashnikova, D. O. Utkin, D. V. Blinov, J.-C. Gris, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +13 more
doaj   +1 more source