Results 31 to 40 of about 60,545 (283)

Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease. [PDF]

PLoS ONE, 2016
Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors.
Alessandra Casonato, Maria Grazia Cattini, Viviana Daidone, Elena Pontara, Antonella Bertomoro, Paolo Prandoni   +5 more
doaj   +1 more source

ADAMTS-13 proteolyzed by thrombin has reduced affinity for von Willebrand factor (VWF)

, 2011
(A) 6 n ADAMTS-13, 60 n thrombin-cleaved ADAMTS-13 (ADAMTS-13/FIIa) or 60 n thrombin-cleaved ADAMTS-13/6 n ADAMTS-13 (10:1 mix) was incubated with 10 n purified plasma-derived VWF in the presence of 1.5 urea and 5 m BaCl.
C K N K CHION (48919), S ZANARDELLI (48920), J T B CRAWLEY (48922), J K LAM (48918), D A LANE (48921)   +4 more
core   +1 more source

ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice

TH Open, 2017
Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky, Melanie Demers, Kimberly Martinod, Maureen Gallant, Stephen M. Cifuni, Amlan Biswas, Scott Snapper, Denisa D. Wagner   +7 more
doaj   +1 more source

Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. [PDF]

PLoS ONE, 2014
BACKGROUND:The coagulation protein von Willebrand Factor (VWF) is known to be elevated in pregnancy. However, the timing and nature of changes in VWF and associated parameters throughout pregnancy are not well understood.
Danielle N Drury-Stewart, Kerry W Lannert, Dominic W Chung, Gayle T Teramura, James C Zimring, Barbara A Konkle, Hilary S Gammill, Jill M Johnsen   +7 more
doaj   +1 more source

Frequency weightings of hand-transmitted vibration for predicting vibration-induced white finger

Scandinavian Journal of Work, Environment & Health, 2011
OBJECTIVE: The aim of this study was to investigate the performance of four frequency weightings for hand-transmitted vibration to predict the incidence of vibration-induced white finger (VWF).
Massimo Bovenzi, Iole Pinto, Francesco Picciolo, Marcella Mauro, Federico Ronchese   +4 more
doaj   +1 more source

Comparative analysis of TRPM8 gene and COPD markers expression in rat lungs following exposure to cigarette smoke and tobacco aerosol

Acta Biomedica Scientifica
Background. Chronic Obstructive Pulmonary Disease (COPD) remains a global medical and social problem. The ion channel TRPM8, a cold receptor, is known to be involved in the pathogenesis of the disease.
P. D. Timkin, M. A. Kiselev, D. A. Shapovalova, D. E. Naumov, P. M. Linskaya, E. A. Borodin   +5 more
doaj   +1 more source

A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]

PLoS ONE, 2011
The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang, Zhenni Ma, Ningzheng Dong, Fang Liu, Jian Su, Yiming Zhao, Fei Shen, Anyou Wang, Changgeng Ruan   +8 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

Research and Practice in Thrombosis and Haemostasis, 2020
Background Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF).
Jessica Garcia, Veronica H. Flood, Sandra L. Haberichter, Scot A. Fahs, Jeremy G. Mattson, Aron M. Geurts, Mark Zogg, Hartmut Weiler, Qizhen Shi, Robert R. Montgomery   +9 more
doaj   +1 more source

GrM cleaves VWF.

, 2013
(A) Purified plasma VWF (5 µg/mL) was incubated with various purified recombinant granzymes (300 nM) in TBS for 1 hour at 37°C and analyzed by immuno blot, using an antibody against VWF.
Martine J. Hollestelle (345019), Philip G. de Groot (167182), Tom Sprong (278692), Peter J. Lenting (133252), Niels Bovenschen (345021), Ka Wai Lai (345020), Marcel van Deuren (15650)   +6 more
core   +1 more source