Results 11 to 20 of about 56,101 (281)

VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease [PDF]

Blood, 2013
Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.
J. Eikenboom, A.B. Federici, R. J. Dirven, G. Castaman, F. Rodeghiero, U. Budde, R. Schneppenheim, J. Batlle, M. T. Canciani, J. Goudemand, I. Peake, A. Goodeve   +11 more
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The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance [PDF]

Blood Advances, 2018
: Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF,
Ahmad H. Mufti, Kenichi Ogiwara, Laura L. Swystun, Jeroen C.J. Eikenboom, Ulrich Budde, Wilma M. Hopman, Christer Halldén, Jenny Goudemand, Ian R. Peake, Anne C. Goodeve, David Lillicrap, Daniel J. Hampshire   +11 more
doaj   +2 more sources

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

, 2023
Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range, 30-
Dearbhla Doherty (10046030), Pamela A Christopherson (15330705), Jorge Di Paola (15410202), Sandra L Haberichter (12654028), Kevin Ryan (356118), Jamie O'Sullivan (7895630), Zimmerman Program Investigations (17615819), Michelle Lavin (7895933), Niamh M O'Connell (11596417), James O'Donnell (7895615), Paula D James (10685405), Mary Byrne (4321339), Margaret Nolan (7948622)   +12 more
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VWF-pHluorin acts as an intraluminal pH-indicator for WPB.

, 2022
HUVEC cotransfected with P-sel-lum-mRFP and VWF-phluorin were incubated with 40 mM NH4Cl for 3 h and then analyzed by live cell confocal microscopy. Shown are images of maximum intensity projections of z-stacks. Cell circumferences are indicated by lines.
Julian Terglane (12975565), Volker Gerke (117510), Dirk Menche (1426639)   +2 more
core   +1 more source

Functioning of the ADAMTS-13/vWF axis and its clinical significance

Акушерство, гинекология и репродукция, 2023
Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF)
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, J.-C. Gris, A. E. Malikova, D. V. Blinov, V. I. Tsibizova, N. D. Degtyareva, S. V. Martirosyan, A. D. Makatsariya   +12 more
doaj   +1 more source

VWF-pHluorin-mRFP reports neutralization of WPB upon treatment with bafilomycin A1.

, 2022
A. Colocalization of fluorescence signals emitted by pHluorin and mRFP both fused in tandem to VWF in HUVEC treated with the V-ATPase-specific inhibitor bafilomycin A1.
Julian Terglane (12975565), Volker Gerke (117510), Dirk Menche (1426639)   +2 more
core   +1 more source

Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Акушерство, гинекология и репродукция, 2023
Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. D. Degtyareva, A. V. Mulenkova, J.-C. Gris, M. V. Kvaratskheliia, E. Grandone, F. E. Yakubova, D. V. Blinov, A. D. Makatsariya   +14 more
doaj   +1 more source

VWF and complement [PDF]

Blood, 2015
In this issue of Blood , Feng and coworkers present data suggesting a role for von Willebrand factor (VWF) in the proteolytic inactivation of complement C3b by factor I (CFI).[1][1] Whereas smaller VWF multimers, especially dimers, tetramers, and hexamers, enhance C3b inactivation by CFI, large ...
openaire   +2 more sources

Neutrophil extracellular traps: a role in inflammation and dysregulated hemostasis as well as in patients with COVID-19 and severe obstetric pathology

Акушерство, гинекология и репродукция, 2021
Numerous studies have proven a close relationship between inflammatory diseases and the state of hypercoagulability. In fact, thromboembolic complications represent one of the main causes of disability and mortality in acute and chronic inflammatory ...
A. D. Makatsariya, E. V. Slukhanchuk, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, N. A. Makatsariya, S. V. Akinshina, A. S. Shkoda, L. L. Pankratyeva, G. C. Di Renzo, G. Rizzo, K. N. Grigorieva, V. I. Tsibizova, J.-C. Gris, I. Elalamy   +14 more
doaj   +1 more source

VWF clearance: it’s glycomplicated [PDF]

Blood, 2018
In this issue of Blood , Ward et al demonstrate that a loss of sialic acids turns von Willebrand factor (VWF) into a ligand for the scavenger-receptor macrophage galactose-type lectin (MGL ...
Denis, Cécile, Lenting, Peter
openaire   +2 more sources