VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease [PDF]
Blood, 2013 Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.
J. Eikenboom +11 more
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von Willebrand Factor fibers formed at pathological high shear provide a scaffold for α-synuclein binding and aggregation [PDF]
Scientific Reportsα-Synuclein (αSyn) is an intrinsically disordered protein whose misfolding and aggregation promotes various synucleinopathies. Potentially relevant to the biophysics of αSyn-dependent pathology as well as seed amplification assays, we tested fibrous von ...
Jason M. Rossi, Scott L. Diamond
doaj +2 more sources
The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance [PDF]
Blood Advances, 2018 : Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF,
Ahmad H. Mufti +11 more
doaj +3 more sources
CURRENT KNOWLEDGE ON THE PATHOGENIC MECHANISMS OF HENOCH-SCHOENLEIN PURPURA IN CHILDREN [PDF]
Trakia Journal of Sciences, 2021 The Schӧnlein-Henoch vasculitis is an IgA-mediated inflammation of small vessels. The main clinical manifestation is palpable purpura without thrombocytopenia, manifested by bilateral symmetrical distribution on both lower limbs, abdominal pain, often ...
A.Vasileva, Iv. Chakarov, P. Chakarova
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Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance [PDF]
, 2023 Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range, 30-
Dearbhla Doherty (10046030) +12 more
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Prognostic value of von Willebrand factor in clinical practice
Акушерство, гинекология и репродукция, 2022 The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva +12 more
doaj +1 more source
VWF-pHluorin acts as an intraluminal pH-indicator for WPB. [PDF]
, 2022 HUVEC cotransfected with P-sel-lum-mRFP and VWF-phluorin were incubated with 40 mM NH4Cl for 3 h and then analyzed by live cell confocal microscopy. Shown are images of maximum intensity projections of z-stacks. Cell circumferences are indicated by lines.
Julian Terglane (12975565) +2 more
core +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk +10 more
doaj +1 more source
VWF-pHluorin-mRFP reports neutralization of WPB upon treatment with bafilomycin A1. [PDF]
, 2022 A. Colocalization of fluorescence signals emitted by pHluorin and mRFP both fused in tandem to VWF in HUVEC treated with the V-ATPase-specific inhibitor bafilomycin A1.
Julian Terglane (12975565) +2 more
core +1 more source
Neonatal thrombosis: risk factors and principles of prophylaxis
Акушерство, гинекология и репродукция, 2021 Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration.
A. V. Vorobev +9 more
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