Results 11 to 20 of about 60,545 (283)
The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance [PDF]
Blood Advances, 2018 : Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF,
Ahmad H. Mufti +11 more
doaj +2 more sources
Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance [PDF]
, 2023 Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range, 30-
Dearbhla Doherty (10046030) +12 more
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Molecular Mechanisms of vWF Secretion [PDF]
, 2014 von Willebrand factor (vWF) secreted by endothelial cells (EC) is essential for hemostasis and thrombosis. However the molecular mechanism of vWF secretion is poorly understood.
Luiza Rusu (7973144)
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VWF-pHluorin acts as an intraluminal pH-indicator for WPB.
, 2022 HUVEC cotransfected with P-sel-lum-mRFP and VWF-phluorin were incubated with 40 mM NH4Cl for 3 h and then analyzed by live cell confocal microscopy. Shown are images of maximum intensity projections of z-stacks. Cell circumferences are indicated by lines.
Julian Terglane (12975565) +2 more
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VWF-pHluorin-mRFP reports neutralization of WPB upon treatment with bafilomycin A1.
, 2022 A. Colocalization of fluorescence signals emitted by pHluorin and mRFP both fused in tandem to VWF in HUVEC treated with the V-ATPase-specific inhibitor bafilomycin A1.
Julian Terglane (12975565) +2 more
core +1 more source
Functioning of the ADAMTS-13/vWF axis and its clinical significance
Акушерство, гинекология и репродукция, 2023 Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF)
K. N. Grigoreva +12 more
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Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation
Акушерство, гинекология и репродукция, 2023 Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva +14 more
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Blood, 2015 In this issue of Blood , Feng and coworkers present data suggesting a role for von Willebrand factor (VWF) in the proteolytic inactivation of complement C3b by factor I (CFI).[1][1] Whereas smaller VWF multimers, especially dimers, tetramers, and hexamers, enhance C3b inactivation by CFI, large ...
openaire +2 more sources
Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]
, 2009 Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor +10 more
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Акушерство, гинекология и репродукция, 2021 Numerous studies have proven a close relationship between inflammatory diseases and the state of hypercoagulability. In fact, thromboembolic complications represent one of the main causes of disability and mortality in acute and chronic inflammatory ...
A. D. Makatsariya +14 more
doaj +1 more source