Results 21 to 30 of about 56,156 (204)

VWF, Platelets and the Antiphospholipid Syndrome [PDF]

International Journal of Molecular Sciences, 2021
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Laboratory criteria for the classification of APS include the detection of lupus anticoagulant (LAC), anti-cardiolipin (aCL) antibodies and anti-β2glycoprotein I (aβ2GPI) antibodies.
Shengshi Huang, Marisa Ninivaggi, Walid Chayoua, Bas de Laat   +3 more
openaire   +3 more sources

Immunofluorescent staining with vWF. [PDF]

, 2021
Immunofluorescent staining with vWF showed a decrease in the number of vWF-positive cells in the group with BOO and an increase in vWF-positive cells after transplantation of hMSCs. The effect was enhanced by hMSCs.HGF. The merged cells expressing yellow
Sung Sik Choi (11868915), Yun Seob Song (11868921), Seung U. Kim (23123), Hee Jo Yang (11868912), Jae Heon Kim (10454261), Hong J. Lee (11868918)   +5 more
core   +1 more source

Pathogenetic and prognostic significance of inflammation and altered ADAMTS-13/vWF axis in patients with severe COVID-19

Акушерство, гинекология и репродукция, 2022
Introduction. Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass endothelial damage followed
V. O. Bitsadze, J. Kh. Khizroeva, J.-Ch. Gris, S. Schulman, A. S. Shkoda, M. V. Tretyakova, N. A. Makatsariya, E. V. Slukhanchuk, L. L. Pankratyeva, M. I. Petrovskiy, I. V. Mashechkin, D. V. Blinov, V. I. Tsibizova, Z. K. Gadaeva, S. S. Panshin, N. V. Samburova, A. D. Makatsariya   +16 more
doaj   +1 more source

Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women

Акушерство, гинекология и репродукция, 2023
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya   +11 more
doaj   +1 more source

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update

Platelets, 2023
ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee, Neil V. Morgan, Jonas Emsley   +2 more
doaj   +1 more source

Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor

Biology Open, 2021
Arf GTPase-Activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors (Arfs), which are critical to form transport intermediates.
Asano Watanabe, Hikari Hataida, Naoya Inoue, Kosuke Kamon, Keigo Baba, Kuniaki Sasaki, Rika Kimura, Honoka Sasaki, Yuka Eura, Wei-Fen Ni, Yuji Shibasaki, Satoshi Waguri, Koichi Kokame, Yoko Shiba   +13 more
doaj   +1 more source

Functioning of the ADAMTS-13/vWF axis and its clinical significance

Акушерство, гинекология и репродукция, 2023
Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF)
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, J.-C. Gris, A. E. Malikova, D. V. Blinov, V. I. Tsibizova, N. D. Degtyareva, S. V. Martirosyan, A. D. Makatsariya   +12 more
doaj   +1 more source

vWF immunostaining. [PDF]

, 2022
hVICs and hVECs stained for vWF (green), phalloidin (red), and DAPI (blue). Scale bars represent 100μm.
Karen Callon (3219756), Robert Walker (78026), Paget Milsom (12889989), Jillian Cornish (3219759), Marcus Ground (12889983), Steve Waqanivavalagi (12889986), Young-Eun Park (11607026)   +6 more
core   +1 more source

Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Акушерство, гинекология и репродукция, 2023
Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. D. Degtyareva, A. V. Mulenkova, J.-C. Gris, M. V. Kvaratskheliia, E. Grandone, F. E. Yakubova, D. V. Blinov, A. D. Makatsariya   +14 more
doaj   +1 more source

VWF and complement [PDF]

Blood, 2015
In this issue of Blood , Feng and coworkers present data suggesting a role for von Willebrand factor (VWF) in the proteolytic inactivation of complement C3b by factor I (CFI).[1][1] Whereas smaller VWF multimers, especially dimers, tetramers, and hexamers, enhance C3b inactivation by CFI, large ...
openaire   +2 more sources