Post-VX exposure treatment of rats with engineered phosphotriesterases [PDF]
Archives of Toxicology, 2021 The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient.
Lisa Stigler +9 more
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VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results. [PDF]
PLoS ONE, 2011 Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has ...
Matthew W Peterson +5 more
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Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed
Jorge Alberto Valle da Silva +4 more
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Global Security: Health, Science and Policy, 2020 VX is a strong nerve-gas agent. In this paper, murder or injury of human made by VX is reported. First use of VX against human was made by Aum Shimrikyo in 1994 and 1995. More recently, VX was used in the assassination of Mr. Kim Jong-Nam in Kuala Lumpur,
Anthony T. Tu
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VX‐765 alleviates motor and cognitive impairments via inhibiting PANoptosis activation in the neonatal rats after hypoxic–ischemic brain damage [PDF]
Pediatric DiscoveryNeonatal hypoxia–ischemia (HI) is one of the main factors that cause neonatal severe neurologic impairment and death. Shown by a large number of studies, caspase‐1 plays a significant effect in diseases such as hypoxic–ischemic brain damage (HIBD) and ...
Xiaohuan Li +5 more
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Clinical and Translational Science, 2022 Selective inhibition of certain voltage‐gated sodium channels (Navs), such as Nav1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neuronal ...
Hemme J. Hijma +3 more
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Journal of Diabetes Investigation, 2022 Introduction As a lytic inflammatory cell death, pyroptosis has been recently described but has not been unequivocally elucidated in diabetic nephropathy (DN).
Si Wen +5 more
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The Pulsation Spectrum of VX Hydrae [PDF]
Publications of the Astronomical Society of the Pacific, 2009 14 pages, 5 figures, published in Publications of the Astronomical Society of the Pacific, v.121, p.1076 (October 2009)
Templeton, M. R. +5 more
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Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur mustard, soman and VX [PDF]
, 2019 Background/Aims: Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a “therapeutic” window in which to mitigate skin absorption.
Chilcott, Robert +2 more
core +4 more sources
Assessment of Seminal L-Carnitine in Infertile Men with Varicocele [PDF]
Egyptian Journal of Medical Research, 2022 Introduction: Most studies that linked varicocele (Vx) with male infertility focused mainly on the testis affection, yet it was suggested that Vx can disturb also the epididymis that plays a central role in sperm maturation.
Mohamed Aabdallah +3 more
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