Results 41 to 50 of about 252,763 (309)

Noot bij de vertaling van Geologia di un padre van Valerio Magrelli

Incontri: Rivista Europea di Studi Italiani, 2017
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Emilia Menkveld
doaj   +1 more source

Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study

Biomolecules, 2020
In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve agent ...
Jorge Alberto Valle da Silva, Ander Francisco Pereira, Steven R. LaPlante, Kamil Kuca, Teodorico Castro Ramalho, Tanos Celmar Costa França   +5 more
doaj   +1 more source

Investigation of the Colorimetric Characteristics of VX in Squaraine-Based Solutions

Chemosensors, 2023
Colorimetry is an important on-site detection method for organophosphorus compounds. O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is recognized as one of the deadliest organophosphorus chemical agents, and the rapid on-site detection ...
Bin Du, Shu Geng, Wei Cao, Lei Guo, Jianjie Xu, Feng Huang, Lina Chen   +6 more
doaj   +1 more source

Valerio Magrelli. Geologia di un padre (fragmenten)

Incontri: Rivista Europea di Studi Italiani, 2017
Vertaling: Emilia ...
Emilia Menkveld
doaj   +1 more source

Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel

Scientific Reports, 2023
F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation.
Mario Renda, Marilia Barreca, Anna Borrelli, Virginia Spanò, Alessandra Montalbano, Maria Valeria Raimondi, Roberta Bivacqua, Ilaria Musante, Paolo Scudieri, Daniela Guidone, Martina Buccirossi, Michele Genovese, Arianna Venturini, Tiziano Bandiera, Paola Barraja, Luis J. V. Galietta   +15 more
doaj   +1 more source

Drought stress during the reproductive stage of two soybean lines [PDF]

Pesquisa Agropecuária Brasileira, 2020
: The objective of this work was to evaluate the effects of drought stress in the reproductive stage (R3) on the physiological parameters and grain yield of two soybean (Glycine max) lines.
Vanessa do Rosário Rosa, Adinan Alves da Silva, Danielle Santos Brito, José Domingos Pereira Júnior, Cíntia Oliveira Silva, Maximiller Dal-Bianco, Juraci Alves de Oliveira, Cleberson Ribeiro   +7 more
doaj   +2 more sources

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway [PDF]

, 2018
PURPOSE: Protecting the heart from ischaemia-reperfusion (IR) injury is a major goal in patients presenting with an acute myocardial infarction. Pyroptosis is a novel form of cell death in which caspase 1 is activated and cleaves interleukin 1β.
Arjun, S, Davidson, SM, Do Carmo, H, Petrucci, O, Yellon, DM   +4 more
core   +1 more source

VX‐445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

New England Journal of Medicine, 2018
BACKGROUND VX‐445 is a next‐generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function in patients with cystic fibrosis when administered with tezacaftor and ivacaftor (VX‐445 ...
D. Keating, G. Marigowda, L. Burr, C. Daines, M. Mall, E. McKone, Bonnie W. Ramsey, S. Rowe, Laura A. Sass, E. Tullis, C. Mckee, S. Moskowitz, S. Robertson, J. Savage, C. Simard, F. van Goor, D. Waltz, F. Xuan, T. Young, J. Taylor-Cousar   +19 more
semanticscholar   +1 more source

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. [PDF]

, 2014
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane regulator (CFTR) that result in reduced anion conductance at the apical membrane of secretory epithelia.
Apaja, Pirjo M., Avramescu, Radu G., Bagdany, Miklos, Borot, Florence, Finkbeiner, Walter E., Hegedus, Tamas, Lukacs, Gergely L., Perdomo, Doranda, Phuan, Puay-Wah, Szollosi, Daniel, Veit, Guido, Verkman, Alan S., Wu, Yu-Sheng   +12 more
core   +1 more source

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source