Wallerian degeneration as a therapeutic target in traumatic brain injury. [PDF]
Curr Opin Neurol, 2019 PURPOSE OF REVIEW Diffuse or traumatic axonal injury is one of the principal pathologies encountered in traumatic brain injury (TBI) and the resulting axonal loss, disconnection, and brain atrophy contribute significantly to clinical morbidity and ...
Koliatsos VE, Alexandris AS.
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MRI of Wallerian Degeneration in the Brainstem: A Pictorial Essay [PDF]
Journal of the Belgian Society of Radiology, 2021 Wallerian degeneration of the cerebral peduncle is a common MRI finding after cerebral injury. The degree of peduncular atrophy reflects the extent of damage in the corticospinal tract.
Nico Hustings, Marc Lemmerling
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Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Mutations in the nicotinamide adenine dinucleotide (NAD+) biosynthesis pathway are associated with progressive neurodegeneration; neuronal injury causes rapid breakdown of damaged axons and dendrites.
Ji H, Sapar ML, Sarkar A, Wang B, Han C.
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Wallerian degeneration of the ipsilateral middle cerebellar peduncle after lower pontine paramedian infarct diagnosed by magnetic resonance imaging [PDF]
Radiology Case Reports, 2023 We reported a case of Wallerian degeneration of the unilateral middle cerebellar peduncle (MCP) that developed after ipsilateral paramedian lower pontine infarction. The patient was a 70-year-old woman with right hemiparesis and dysarthria.
Akira Uchino, MD, PhD +1 more
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Imaging resident and recruited macrophage contribution to Wallerian degeneration. [PDF]
J Exp Med, 2020 This work describes the spatiotemporal orchestration of recently recruited monocyte-derived and resident macrophages during Wallerian degeneration induced by chronic constriction injury of the sciatic nerve and unveils distinct contribution of these two ...
Boissonnas A +10 more
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MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. [PDF]
PLoS ONE, 2013 Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a neuroprotective phenotype conferred ...
Catherine Evans +3 more
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Wallerian degeneration in cervical spinal cord tracts is commonly seen in routine T2-weighted MRI after traumatic spinal cord injury and is associated with impairment in a retrospective study. [PDF]
Eur Radiol, 2021 Wallerian degeneration (WD) is a well-known process after nerve injury. In this study, occurrence of remote intramedullary signal changes, consistent with WD, and its correlation with clinical and neurophysiological impairment were assessed after ...
Fischer T +4 more
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The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves [PDF]
BMC Neuroscience, 2005 Background The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on statistical observations at ...
Grumme Daniela S +6 more
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Progressive Multifocal Leukoencephalopathy with Wallerian Degeneration [PDF]
European Neurology, 2011 A 39-year-old male presented with slurred speech, left hand weakness, gait unsteadiness and headaches over a period of 4 weeks. A brain MRI revealed a right motor strip lesion with Wallerian degeneration along the pyramidal tract plus brain stem and cerebellar FLAIR changes without enhancement (fig. (fig.1).1). Laboratory findings included a CD4 count
Ali Mahta, Ryan Y. Kim, Santosh Kesari
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Axon death signalling in Wallerian degeneration among species and in disease. [PDF]
Open Biol, 2019 Axon loss is a shared feature of nervous systems being challenged in neurological disease, by chemotherapy or mechanical force. Axons take up the vast majority of the neuronal volume, thus numerous axonal intrinsic and glial extrinsic support mechanisms ...
Llobet Rosell A, Neukomm LJ.
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