Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis [PDF]
Journal of Neuroinflammation, 2017 BackgroundAxonal damage and loss substantially contribute to the incremental accumulation of clinical disability in progressive multiple sclerosis. Here, we assessed the amount of Wallerian degeneration in brain tissue of multiple sclerosis patients in ...
Shailender Singh +7 more
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Development and Characterisation of an in vitro Model of Wallerian Degeneration. [PDF]
Front Bioeng Biotechnol, 2020 Following peripheral nerve injury, a sequence of events termed Wallerian degeneration (WD) takes place at the distal stump in order to allow the regenerating axons to grow back toward the target organs. Schwann cells (SCs) play a lead role in this by initiating the inflammatory response attracting macrophages and immune cells, as well as producing ...
Elsayed H +9 more
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The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1. [PDF]
Front Cell Neurosci, 2019 After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery.
Pellegatta M, Taveggia C.
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Critical signaling pathways during Wallerian degeneration of peripheral nerve
Neural Regeneration Research, 2017 Wallerian degeneration is a critical biological process that occurs in distal nerve stumps after nerve injury. To systematically investigate molecular changes underlying Wallerian degeneration, we used a rat sciatic nerve transection model to examine ...
Qiong Cheng +3 more
doaj +2 more sources
Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury [PDF]
Neural Regeneration ResearchMacrophages play an important role in peripheral nerve regeneration, but the specific mechanism of regeneration is still unclear. Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral ...
Yuhui Kou +5 more
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Acute Wallerian degeneration of middle cerebellar peduncles due to basilar artery thrombosis [PDF]
Indian Journal of Radiology and Imaging, 2013 Wallerian degeneration (WD) is the process of demyelination and disintegration of the distal axonal segment following the interruption of the axonal integrity or damage to the neuron.
Foram Gala +3 more
doaj +2 more sources
Wallerian Degeneration of the Pyramidal Tract. [PDF]
Dtsch Arztebl Int, 2022 Forbrig R, Danek A.
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NMNAT Proteins that Limit Wallerian Degeneration Also Regulate Critical Period Plasticity in the Visual Cortex. [PDF]
eNeuro, 2019 Many brain regions go through critical periods of development during which plasticity is enhanced. These critical periods are associated with extensive growth and retraction of thalamocortical and intracortical axons.
van Lier M +7 more
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Wallerian degeneration: From mechanism to disease to imaging [PDF]
HeliyonWallerian degeneration (WD) was first discovered by Augustus Waller in 1850 in a transection of the glossopharyngeal and hypoglossal nerves in frogs. Initial studies suggested that the formation mechanism of WD is related to the nutrition of neuronal ...
Ruiqi Tian +4 more
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