Results 31 to 40 of about 315,901 (259)

Signaling mechanisms regulating Wallerian degeneration [PDF]

Current Opinion in Neurobiology, 2014
Wallerian degeneration (WD) occurs after an axon is cut or crushed and entails the disintegration and clearance of the severed axon distal to the injury site. WD was initially thought to result from the passive wasting away of the distal axonal fragment, presumably because it lacked a nutrient supply from the cell body.
M. Freeman
semanticscholar   +5 more sources

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca2+ Influx but Only Modestly Influenced by Mitochondria

Cell Reports, 2015
Axon injury leads to rapid depletion of NAD-biosynthetic enzyme NMNAT2 and high levels of its substrate, NMN. We proposed a key role for NMN in Wallerian degeneration but downstream events and their relationship to other mediators remain unclear.
Andrea Loreto, Michele Di Stefano, Martin Gering, Laura Conforti   +3 more
doaj   +2 more sources

Wallerian degeneration in experimental focal cortical ischemia

Brain Research Bulletin, 2019
Wallerian degeneration (WaD), commonly secondary to cerebral infarction, is the descending damage of fiber tracts with their accompanying myelin sheaths. However, whether this sequential injury can occur in non-ischemic corpus callosum (CC) and striatum in focal cortical ischemic model has not been fully demonstrated.
Meng Zuo, Hongquan Guo, Ting Wan, Nana Zhao, Haodi Cai, M. Zha, Y. Xiong, Yi Xie, Ruidong Ye, Xinfeng Liu   +9 more
semanticscholar   +3 more sources

The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury

Neural Regeneration Research, 2014
Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0–4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood.
Dengbing Yao, Leilei Gong, Yun Zhu, Xi Xu, Huaiqin Li, Weimin Guo, Qin Zhao   +6 more
openalex   +2 more sources

Wallerian Degeneration [PDF]

Definitions, 2020

openalex   +2 more sources

Neuritin accelerates Schwann cell dedifferentiation via PI3K/Akt/mTOR signalling pathway during Wallerian degeneration. [PDF]

J Cell Mol Med
Liu J, Guan X, Zheng S, Shi J, Wang X, Shen Z, Chen Z, Liao C, Zhang Z.   +8 more
europepmc   +2 more sources

Clinical and magnetic resonance imaging features in acute ischemic stroke with early wallerian degeneration: a case-control study. [PDF]

BMC Neurol
Ota K, Nakazato Y, Seo K, Kawasaki H, Okada M, Mithufuji T, Ito Y, Yamamoto T.   +7 more
europepmc   +2 more sources

Magnetic resonance imaging evaluation of Wallerian degeneration of bilateral middle cerebellar peduncles after pontine infarction. [PDF]

Saudi Med J, 2019
Yin S, Jin CX, Zhang DP, Peng YF.
europepmc   +3 more sources

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

Cell Reports, 2016
Yuya Yamagishi, Marc Tessier‐Lavigne
openalex   +2 more sources

Neurodegeneration in multiple sclerosis

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey, Kedar R. Mahajan, Tara M. DeSilva   +2 more
wiley   +1 more source