Neurobiology of Disease, 2020 Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1.
Andrea Loreto +11 more
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Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]
, 2020 The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David +6 more
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Wallerian degeneration in central nervous system: dynamic associations between diffusion indices and their underlying pathology. [PDF]
PLoS ONE, 2012 BACKGROUND: Although diffusion tensor imaging has been used to monitor Wallerian degeneration, the exact relationship between the evolution of diffusion indices and its underlying pathology, especially in central nervous system, remains largely unknown ...
Wen Qin +7 more
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ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]
, 2004 Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Anderson, PN +6 more
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Pathological classification of equine recurrent laryngeal neuropathy [PDF]
, 2018 Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle ...
Draper, A C E, Piercy, R J
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Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress
ASN Neuro, 2019 During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells.
Muwoong Kim +8 more
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A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]
, 2012 Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C. +7 more
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New zebrafish models of neurodegeneration [PDF]
, 2015 In modern biomedicine, the increasing need to develop experimental models to further our understanding of disease conditions and delineate innovative treatments has found in the zebrafish (Danio rerio) an experimental model, and indeed a valuable asset ...
A Nasevicius +28 more
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Neural Regeneration Research, 2019 Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ.
Yao-Fa Lin +4 more
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Wallerian degeneration: the innate-immune response to traumatic nerve injury
Journal of Neuroinflammation, 2011 Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed
Rotshenker Shlomo
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