Results 61 to 70 of about 19,232 (215)
Advanced Science, EarlyView.This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu +12 more
wiley +1 more source
Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.
PLoS Biology, 2010 The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival.
Jonathan Gilley, Michael P Coleman
doaj +1 more source
Annals of Neurology, EarlyView.We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton +11 more
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2021 The bilateral and symmetrical Wallerian degeneration (WD) of the middle cerebella peduncles (MCPs) is rarely reported in pontine hemorrhage. We described a patient with WD of bilateral MCPs secondary to a strip of unilateral and transversal pontine ...
Dawei Chen, Jin Shi
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore +7 more
wiley +1 more source
Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons [PDF]
, 2014 Mitochondrial dysfunction is the underlying cause of many neurological disorders, including peripheral neuropathies. Mitochondria rely on a proton gradient to generate ATP and interfering with electron transport chain function can lead to the deleterious
DiAntonio, Aaron +2 more
core +2 more sources
Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng +6 more
wiley +1 more source
Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury. [PDF]
, 2012 BACKGROUND: We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats.
Bull, Natalie D +4 more
core +3 more sources
Movement Disorders, EarlyView.The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger +1 more
wiley +1 more source
Scientific Reports, 2023 The cellular and molecular underpinnings of Wallerian degeneration have been robustly explored in laboratory models of successful nerve regeneration.
Wesley S. Warner +4 more
doaj +1 more source