Results 81 to 90 of about 19,232 (215)

Progressive Multifocal Leukoencephalopathy with Wallerian Degeneration [PDF]

European Neurology, 2011
A 39-year-old male presented with slurred speech, left hand weakness, gait unsteadiness and headaches over a period of 4 weeks. A brain MRI revealed a right motor strip lesion with Wallerian degeneration along the pyramidal tract plus brain stem and cerebellar FLAIR changes without enhancement (fig. ​(fig.1).1). Laboratory findings included a CD4 count
Ali, Mahta, Ryan Y, Kim, Santosh, Kesari
openaire   +2 more sources

Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain [PDF]

, 2016
Background: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats. Methods: A control, mild, moderate, or severe contusion injury
Budde, Matthew D., Jirjis, Michael B., Kalinosky, Benjamin, Kurpad, Shekar N., Vedantam, Aditya   +4 more
core   +1 more source

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy [PDF]

, 2016
Acknowledgments Blood biochemistry analysis and serum analysis were performed by the Easter Bush Pathology Department, University of Edinburgh. Animal husbandry was performed by Centre for Integrative Physiology bio-research restructure technical staff ...
Azzouz, Mimoun, Becker, Catherina G., Boyd, Penelope, Come, Julian, Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Karyka, Evangelina, Martinat, Cecile, Parson, Simon H., Powis, Rachael A., Szunyogova, Eva, Thomson, Derek, Wishart, Thomas M., Zheng, Yinan   +15 more
core   +3 more sources

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Concepts for regulation of axon integrity by enwrapping glia [PDF]

, 2013
Long axons and their enwrapping glia (Schwann cells and oligodendrocytes) form a unique compound structure that serves as conduit for transport of electric and chemical information in the nervous system.
Beirowski, Bogdan
core   +3 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

Neurobiology of Disease, 2013
In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus Waller first described this process after transection of axons in 1850, the molecular mechanisms may be ...
Marek Ma, Toby A. Ferguson, Kathleen M. Schoch, Jian Li, Yaping Qian, Frances S. Shofer, Kathryn E. Saatman, Robert W. Neumar   +7 more
doaj   +1 more source

Wallerian Degeneration Surveyed in Poliomyelitis [PDF]

, 2017
Poliomyelitis is a highly infectious disease rendering varying degrees of respiratory illness, gastroenteritis, malaise and potentially severe forms of paralysis. Infection is generated by a virus belonging in the Picornaviridae family.
Kelliher, Kevin R., Pavlyukovets, Alyesia, Song, Frank Jr., Terfera, David R., Zitolo, Katherine   +4 more
core  

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Relative Effects of Various Factors on Ice Ball Formation and Ablation Zone Size During Ultrasound-Guided Percutaneous Cryoneurolysis: A Laboratory Investigation to Inform Clinical Practice and Future Research

Pain and Therapy, 2023
Introduction Ultrasound-guided percutaneous cryoneurolysis provides analgesia using cold temperatures to reversibly ablate peripheral nerves. Cryoneurolysis probes pass a gas through a small internal annulus, rapidly lowering the pressure and temperature,
Engy T. Said, Brennan P. Marsh-Armstrong, Seth J. Fischer, Preetham J. Suresh, Matthew W. Swisher, Andrea M. Trescot, J. David Prologo, Baharin Abdullah, Brian M. Ilfeld   +8 more
doaj   +1 more source