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Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy [PDF]
Drugs and Drug Candidates, 2023 The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari +5 more
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Vitamin D promotes apoptosis and enhances cisplatin sensitivity in bladder cancer cells by inhibiting the Warburg effect through the AKT/mTOR pathway [PDF]
BMC UrologyObjective Patients with bladder cancer (BCa) have a poor prognosis and are prone to metastasis. Deficiency of 1,25-dihydroxyvitamin D3 (VD) is associated with increased incidence and decreased survival in various tumors.
Jian Zhou +5 more
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Partners in the Warburg effect [PDF]
eLife, 2016 Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
Joshua D Rabinowitz, Hilary A Coller
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Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer [PDF]
Cell Death and DiseaseThe Warburg effect, also known as aerobic glycolysis, plays a crucial role in the onset and progression of colorectal cancer (CRC), although its mechanism remains unclear.
Ruixue Huo +8 more
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mTORC2 dictates Warburg effect and drug resistance [PDF]
Cell Cycle, 2014 Metabolic reprogramming, a prominent phenotype in cancer cells, is the adaptation to shifts in the usage of metabolites, including glucose, fatty acids, amino acids, and glutamine. The central feature of this adaptation lies in the fact that cancer cells undergo glycolysis even in the presence of ample oxygen, contrary to normal cells.1 This aerobic ...
Kenta Masui +2 more
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Metabolic modelling links Warburg effect to collagen formation, angiogenesis and inflammation in the tumoral stroma. [PDF]
PLoS ONECancer cells are known to express the Warburg effect-increased glycolysis and formation of lactic acid even in the presence of oxygen-as well as high glutamine uptake. In tumors, cancer cells are surrounded by collagen, immune cells, and neoangiogenesis.
Maxime Mahout +4 more
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Fructose in the kidney: from physiology to pathology [PDF]
Kidney Research and Clinical Practice, 2021 The Warburg effect is a unique property of cancer cells, in which glycolysis is activated instead of mitochondrial respiration despite oxygen availability.
Takahiko Nakagawa, Duk-Hee Kang
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Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer [PDF]
BioMed Research International, 2014 Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanisms to a nonoxidative breakdown of ...
González, Claudio Daniel +5 more
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Cancer Medicine, 2023 Background Glioblastoma (GBM), the most common primary malignant brain tumor, has a poor prognosis, with a median survival of only 14.6 months.
Rong Zhang +9 more
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Zhongliu Fangzhi Yanjiu, 2022 Ubiquitin modification and Warburg effect play an important role in the occurrence and development of tumors. The process of tumor ubiquitin modification is closely related to glycolysis, that is, ubiquitin modification in tumor cells can regulate the ...
WANG Fengli, HU Jing
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