Results 11 to 20 of about 106,451 (346)
Partners in the Warburg effect [PDF]
eLife, 2016 Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
Joshua D Rabinowitz, Hilary A Coller
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Nuclear Receptors and the Warburg effect in cancer [PDF]
International Journal of Cancer, 2015 In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen.
Abedin SA +15 more
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The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Xian Wang, Hongchuan Jin
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Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer [PDF]
BioMed Research International, 2014 Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanisms to a nonoxidative breakdown of ...
González, Claudio Daniel +5 more
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The Warburg effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria.
Morten, K, Potter, M, Newport, E
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Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
The Journal of Pathology: Clinical Research, 2022 Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic value in colorectal cancer (CRC), but results remain inconsistent.
Kelly Offermans +9 more
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PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]
, 2015 Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
A Barbarulo +61 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH).
Yunbin Xiao +9 more
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The Warburg effect and its role in cancer detection and therapy [PDF]
, 2009 The Warburg effect is a cellular phenomenon in cancer cells discovered by Otto Warburg in 1924. His findings showed that in normoxic conditions tumor cells primarily use glycolysis for energy production instead of mitochondrial oxidative phosphorylation ...
Christ, Ethan J.
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Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect [PDF]
, 2015 Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The
Demetrius, Lloyd A. +2 more
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