Results 11 to 20 of about 108,453 (351)
The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer:Targets for Effective Therapy with 3-Bromopyruvate [PDF]
, 2016 This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects.
Lis, Paweł +6 more
core +7 more sources
Journal of Hematology & Oncology, 2022 Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression.
Xinyang Zhong +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Atrial fibrosis is the basis for the occurrence and development of atrial fibrillation (AF) and is closely related to the Warburg effect, endoplasmic reticulum stress (ERS) and mitochondrion dysfunctions-induced cardiomyocyte apoptosis. Hydrogen sulfide (
Heng-Jing Hu +12 more
doaj +1 more source
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism [PDF]
BioFactors, 2021 AbstractIt was 80 years after the Otto Warburg discovery of aerobic glycolysis, a major hallmark in the understanding of cancer. The Warburg effect is the preference of cancer cell for glycolysis that produces lactate even when sufficient oxygen is provided.
Dina Johar +6 more
openaire +2 more sources
The Warburg effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria.
Morten, K, Potter, M, Newport, E
openaire +3 more sources
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
The Journal of Pathology: Clinical Research, 2022 Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic value in colorectal cancer (CRC), but results remain inconsistent.
Kelly Offermans +9 more
doaj +1 more source
The Warburg effect and its role in cancer detection and therapy [PDF]
, 2009 The Warburg effect is a cellular phenomenon in cancer cells discovered by Otto Warburg in 1924. His findings showed that in normoxic conditions tumor cells primarily use glycolysis for energy production instead of mitochondrial oxidative phosphorylation ...
Christ, Ethan J.
core +2 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH).
Yunbin Xiao +9 more
doaj +1 more source
PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]
, 2015 Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
A Barbarulo +61 more
core +2 more sources
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer
Frontiers in Oncology, 2020 As shown in our previous study, SIRT6 promotes an aggressive phenotype and the epithelial-mesenchymal transition (EMT) in papillary thyroid cancer (PTC). In this study, we focused on the regulatory axis including SIRT6, autophagy, and the Warburg effect.
Zhou Yang +5 more
doaj +1 more source