Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis [PDF]
Biology, 2021 Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer +4 more
doaj +5 more sources
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer [PDF]
Cell Death and DiseaseThe Warburg effect, also known as aerobic glycolysis, plays a crucial role in the onset and progression of colorectal cancer (CRC), although its mechanism remains unclear.
Ruixue Huo +8 more
doaj +2 more sources
Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer [PDF]
Marine Drugs, 2020 The phenomenon of high sugar consumption by tumor cells is known as Warburg effect. It results from a high glycolysis rate, used by tumors as preferred metabolic pathway even in aerobic conditions.
Sergey A. Dyshlovoy +16 more
doaj +3 more sources
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. [PDF]
PLoS Computational Biology, 2011 The Warburg effect--a classical hallmark of cancer metabolism--is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily on
Tomer Shlomi +4 more
doaj +7 more sources
A negative feedback loop underlies the Warburg effect [PDF]
npj Systems Biology and Applications, 2023 AbstractAerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation.
Alok Jaiswal, Raghvendra Singh
openaire +4 more sources
Effects of Nanoparticle Geometry and Size Distribution on Diffusion Impedance of Battery Electrodes [PDF]
arXiv, 2012 The short diffusion lengths in insertion battery nanoparticles render the capacitive behavior of bounded diffusion, which is rarely observable with conventional larger particles, now accessible to impedance measurements. Coupled with improved geometrical characterization, this presents an opportunity to measure solid diffusion more accurately than the ...
Bazant, M. Z., Song, J.
arxiv +3 more sources
The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells [PDF]
Molecular Cancer, 2009 Background The Warburg effect has been found in a wide spectrum of human cancers, however the underlying mechanisms are still unclear. This study aims to explore the role of cellular oxidative stress in relation to glycolysis and the Warburg effect in ...
Shi Dong-yun +5 more
doaj +5 more sources
P53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect [PDF]
arXivCancer cells exhibit significant alterations in their metabolism, characterised by a reduction in oxidative phosphorylation (OXPHOS) and an increased reliance on glycolysis, even in the presence of oxygen. This metabolic shift, known as the Warburg effect, is pivotal in fuelling cancer's uncontrolled growth, invasion, and therapeutic resistance.
Abukwaik R +3 more
arxiv +3 more sources
HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35 [PDF]
Discover OncologyBackground There are a lot of studies on the treatment of tumors with hyperbaric oxygen, while most of them are in breast cancer, prostate cancer and so on.
Yuting Ding +4 more
doaj +2 more sources
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. [PDF]
, 2022 UNLABELLED: The Warburg effect is the major metabolic hallmark of cancer. According to Warburg himself, the consequence of the Warburg effect is cell dedifferentiation.
Banuelos, Selene +18 more
core +2 more sources