Results 41 to 50 of about 13,460,861 (391)
Cell Death and Disease, 2021 Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely
Rongkun Li +11 more
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Frontiers in Cell and Developmental Biology, 2021 Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic ...
Li Li +4 more
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Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells
International Journal of Molecular Sciences, 2022 Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are defined as a “metabolically abnormal system”. Carbohydrates are metabolically reprogrammed by its metabolizing and catabolizing enzymes in such abnormal cancer cells ...
Abekura Fukushi +3 more
semanticscholar +1 more source
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
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The Warburg effect: a balance of flux analysis [PDF]
Metabolomics, 2014 Cancer metabolism is characterized by increased macromolecular syntheses through coordinated increases in energy and substrate metabolism. The observation that cancer cells produce lactate in an environment of oxygen sufficiency (aerobic glycolysis) is a central theme of cancer metabolism known as the Warburg effect.
Vaitheesvaran, B +6 more
openaire +5 more sources
PLoS ONE, 2019 The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako +2 more
doaj +1 more source
Cell Transplantation, 2021 Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer.
Zhen Li +7 more
doaj +1 more source
A separation of the reactions in photosynthesis by means of intermittent light [PDF]
, 1932 Experiments on photosynthesis in intermittent light have been made on two occasions. Brown and Escombe, in 1905, made use of a rotating sector to study the effect of light intensity on the photosynthesis of leaves.
Arnold, William, Emerson, Robert
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'Reverse Warburg effect' of cancer‑associated fibroblasts (Review).
International Journal of Oncology, 2022 Metabolic reprogramming is one of the main characteristics of malignant tumors. The metabolic reprogramming of tumors is not only related to the characteristics of cancer cells, but also closely related to the tumor microenvironment (TME).
Lin Liang +6 more
semanticscholar +1 more source
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]
, 2019 Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C. +3 more
core +1 more source