Results 41 to 50 of about 106,451 (346)
Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors
Frontiers in Oncology, 2021 Reprogramming of metabolic priorities promotes tumor progression. Our understanding of the Warburg effect, based on studies of cultured cancer cells, has evolved to a more complex understanding of tumor metabolism within an ecosystem that provides and ...
Sayani Patra +19 more
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Warburg′s effect on solid tumors
Saudi Journal of Kidney Diseases and Transplantation, 2014 Lactic acidosis is the result of imbalance between the systemic formation of lactate and its hepatic metabolism. In cancer patients, lactic acidosis is mainly associated with hematologic malignancies (leukemia and lymphomas) and the mechanism is known as Warburg's effect.
Talal El Imad +2 more
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Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism [PDF]
BioFactors, 2021 AbstractIt was 80 years after the Otto Warburg discovery of aerobic glycolysis, a major hallmark in the understanding of cancer. The Warburg effect is the preference of cancer cell for glycolysis that produces lactate even when sufficient oxygen is provided.
Dina Johar +6 more
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Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect
Frontiers in Cell and Developmental Biology, 2018 The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese +3 more
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Molecular Medicine, 2023 Background The main cause of high mortality from sepsis is that immunosuppression leads to life-threatening organ dysfunction, and reversing immunosuppression is key to sepsis treatment. Interferon γ (IFNγ) is a potential therapy for immunosuppression of
Xu-zhe Fu, Yu Wang
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A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]
, 2019 Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C. +3 more
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Warburg effect—damping of electromagnetic oscillations [PDF]
Electromagnetic Biology and Medicine, 2017 Mitochondrial dysfunction is a central defect in cells creating the Warburg and reverse Warburg effect cancers. However, the link between mitochondrial dysfunction and cancer has not yet been clearly explained. Decrease of mitochondrial oxidative energy production to about 50 % in comparison with healthy cells may be caused by inhibition of pyruvate ...
Jiří, Pokorný +2 more
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Biology, 2021 Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer +4 more
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Revisiting the Warburg Effect with Focus on Lactate
Cancers, 2022 Rewired metabolism is acknowledged as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect, is a feature of many cancers. Increased glucose uptake and glycolysis provide intermediates for anabolic reactions necessary for cancer cell proliferation while contributing sufficient energy.
Eva Kocianova +2 more
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Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy
Drugs and Drug Candidates, 2023 The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari +5 more
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