Results 81 to 90 of about 13,460,861 (391)

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

Molecular Cancer
Background The hypoxic tumor microenvironment is a key factor that promotes metabolic reprogramming and vascular mimicry (VM) in ovarian cancer (OC) patients.
Juan Zhang, Ouyang Fan, An-bo Gao, Tian Zeng, Ming Li, Hui Li, Wen-chao Zhou, Qing Gao, Xing Tang, Qun-feng Zhang, Xiao-min Ran, Gang Tian, Xiyun Quan, Zhen-zi Tang, Juan Zou, Yifei Zeng, Yunzhu Long, Yukun Li   +17 more
semanticscholar   +1 more source

Effects of Nanoparticle Geometry and Size Distribution on Diffusion Impedance of Battery Electrodes

, 2012
The short diffusion lengths in insertion battery nanoparticles render the capacitive behavior of bounded diffusion, which is rarely observable with conventional larger particles, now accessible to impedance measurements. Coupled with improved geometrical
Bazant, M. Z., Song, J.
core   +1 more source

Nuclear PKM2 regulates the Warburg effect [PDF]

Cell Cycle, 2013
Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms.
Weiwei Yang, Zhimin Lu
openaire   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth

Cancers
Simple Summary Cancer represents unrestricted growth with the removal of conventional brakes that control growth under normal conditions. This requires novel mechanisms to provide metabolic energy to fuel the rapid growth and also macromolecules to ...
Marilyn Mathew, Nhi T. Nguyen, Yangzom D. Bhutia, Sathish Sivaprakasam, Vadivel Ganapathy   +4 more
semanticscholar   +1 more source

Apigenin Suppresses the Warburg Effect and Stem-like Properties in SOSP-9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway

Evidence-Based Complementary and Alternative Medicine, 2022
Osteosarcoma (OS) is a prevalent primary malignant bone tumor that commonly occurs in children and adolescents. Apigenin (4′,5,7-trihydroxyflavone) is one of the most researched phenolic compounds that exhibits antitumor effects in several cancers.
Yi-huan Shi, Kai Lian, Jiguang Jia
semanticscholar   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Lactic Acidosis and Hypoglycemia in a Patient with Gastric Diffuse Large B-Cell Lymphoma due to the Warburg Effect

Case Reports in Oncology, 2020
Lactic acidosis is pathophysiologically classified into type A and type B. The latter is a rare but potentially life-threatening emergency, mainly described in hematological malignancies.
Takafumi Hamada, Toshinari Kaku, Sumitaka Mitsu, Yoshinori Morita, Nobuhito Ohno, Hironori Yamaguchi   +5 more
doaj   +1 more source

CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR‐433‐3p in non‐small cell lung cancer

Thoracic Cancer, 2022
Background Circular RNAs (circRNAs) participate in the genesis and progression of tumors, including non‐small cell lung cancer (NSCLC). At present, the role and regulatory mechanisms of circRNAs in NSCLC have not been fully elucidated.
Jia Yu, Haining Zhang, Chunsheng Zhao, Guanghui Li, Yingying Zhang, Yang Sun   +5 more
doaj   +1 more source

CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect

Oncology Letters, 2022
Colorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide, with a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is upregulated in CRC and is involved in regulating the apoptosis ...
Wenyu Yang, Yanchun Wang, Chun-lian Tao, Yunhai Li, Sha Cao, Xi-Qian Yang   +5 more
semanticscholar   +1 more source