Results 91 to 100 of about 185,181 (328)

Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose

open access: yesPLoS ONE, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events.
Zhiyuan Ma   +4 more
semanticscholar   +1 more source

Role of rivaroxaban in the management of atrial fibrillation: insights from clinical practice. [PDF]

open access: yes, 2018
© 2018 Vimalesvaran et al. This work is published and licensed by Dove Medical Press Limited.Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and it leads to significant morbidity and mortality, predominantly from ischemic stroke.
Dockrill, Seth J   +2 more
core   +2 more sources

Thrombocytopenia and Anemia After Cardiac Surgery

open access: yes
American Journal of Hematology, EarlyView.
Myriam Beshai   +2 more
wiley   +1 more source

Impact of Age and Factor Xa Inhibitor Concentrations on Bleeding Risk in Patients with Atrial Fibrillation

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
This study aimed to analyze differences in the exposure‐response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and < 80 years. Patients with atrial fibrillation (AF) taking rivaroxaban, apixaban, or edoxaban were enrolled, and a single steady‐state trough concentration was measured.
Shin‐Yi Lin   +7 more
wiley   +1 more source

Protein binding interaction of warfarin and acetaminophen in presence of arsenic and of the biological system

open access: yesBangladesh Journal of Pharmacology, 2008
Equilibrium dialysis was used to study in vitro binding of acetaminophen at physiological pH and temperature in Bovine serum albumin (BSA). The binding of acetaminophen and warfarin mixture was studied to determine the effect of acetaminophen on the ...
Md. Ashraful Alam   +2 more
doaj   +1 more source

New oral anticoagulants and their reversal agents [PDF]

open access: yes, 2018
Atrial fibrillation is a commonly encountered pathology in medical practice, and its prevalence has shown a continuous rise over the past years. Atrial fibrillation has a significant impact on patients\u27 quality of life, not only due to the standard ...
Bodean, Oana   +9 more
core   +1 more source

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler   +11 more
wiley   +1 more source

Legal and professional implications of shared care: a case study in oral anticoagulation stroke prevention therapy. [PDF]

open access: yes, 2015
Policy initiatives and technological advances enable the use of integrated shared care models of healthcare delivery whereby the focus of care is moved from the hospital to the community, and also of models where patients take increasing responsibility ...
Coleman, B   +3 more
core   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen   +12 more
wiley   +1 more source

Profile and outcome of patients with Warfarin Toxicity admitted in a tertiary care hospital in Bhutan: a cross-sectional study investigators and institutions

open access: yesBMC Research Notes, 2023
Objective To study the profile, clinical presentation and outcome of hospital stay among patients admitted with warfarin toxicity at the Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Yeshey Penjore   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy