More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions. [PDF]
, 2018 © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the ...
Farag M +6 more
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Comparison of Safety and Efficacy of Warfarin Versus Rivaroxaban in Northern Chinese Patients With Different CHA2DS2-VASc Score [PDF]
, 2021 Shiwei Xu +4 more
openalex +1 more source
Recanalization of Thrombosed Atrial Flow Regulator in Failing Fontan: A Bridge to Transplant
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT We report the case of a 10‐year‐old boy (41 kg, 133 cm) with hypoplastic left heart syndrome (mitral and aortic atresia), who underwent staged palliation: Norwood‐Sano at 6 days, Glenn at 7 months, and Fontan completion at 3 years using a 16 mm non‐fenestrated extracardiac Gore‐Tex conduit.
Raymond N. Haddad +3 more
wiley +1 more source
Warfarin Resistance: A Case Report
Eurasian Journal of Emergency Medicine, 2019 Warfarin is the most widely prescribed anticoagulant in the world. Patients who need more than 15 mg per day should be considered warfarin-resistant.
Uğur Gönlügür +3 more
doaj +1 more source
Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review [PDF]
, 2016 Objective:Atrial Fibrillation (AF) is associated with dementia. If AF-related cognitive decline is driven by cerebral embolic events, thromboprophylaxis may impact on this.
Lane, Deirdre A. +4 more
core +2 more sources
A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
ChemMedChem, EarlyView.A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova +15 more
wiley +1 more source
Patient Preference and Adherence, 2010 Patrick P Kneeland, Margaret C FangThe University of California, San Francisco Division of Hospital Medicine, San Francisco, CA, USAAbstract: Warfarin therapy reduces morbidity and mortality related to thromboembolism. Yet adherence to long-term warfarin
Patrick P Kneeland, Margaret C Fang
doaj
Molecules, 2017 Human serum albumin (HSA) binds a variety of xenobiotics, including flavonoids and warfarin. The binding of another ligand to the IIA binding site on HSA can cause warfarin displacement and potentially the elevation of its free concentration in blood ...
Hrvoje Rimac +4 more
doaj +1 more source
Real‐World Edoxaban Concentrations in Older Patients Receiving Reduced‐Dose Regimens
Clinical Pharmacology &Therapeutics, EarlyView.Real‐world edoxaban concentrations in older patients receiving reduced‐dose regimens. Low trough concentrations (< 12 ng/mL) were associated with an increased risk of thromboembolism. Among patients meeting the ELDERCARE‐AF criteria, low drug levels were more frequent with the 15 mg regimen than with the 30 mg regimen.
Sung‐Chun Tang +8 more
wiley +1 more source
Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome
International Journal of Cardiology: Heart & Vasculature, 2019 Although non-vitamin-K anticoagulants are now the preferred option for stroke prevention in atrial fibrillation (AF), warfarin is still used in a significant number of patients.
Anke C. Fender, Dobromir Dobrev
doaj +1 more source